Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

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The Hallmarks of Aging

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Microsatellites: simple sequences with complex evolution

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Vascular smooth muscle cells in atherosclerosis

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Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

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The central role of DNA damage in the ageing process

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Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

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The genetics of human ageing

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Common genetic associations between age-related diseases

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DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

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Pathogenic mechanisms of somatic mutation and genome mosaicism in aging

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Mitochondria in the signaling pathways that control longevity and health span

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The architecture of intra-organism mutation rate variation in plants

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Single-cell omics in ageing: a young and growing field

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Applications of Single-Cell DNA Sequencing

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Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

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Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses

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Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

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The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

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Proposed global prognostic score for systemic mastocytosis: a retrospective prognostic modelling study

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Ontogenetic and Pathogenetic Views on Somatic Chromosomal Mosaicism

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Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

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Genome Instability and DNA Repair in Somatic and Reproductive Aging

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Tumor Heterogeneity and Consequences for Bladder Cancer Treatment

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Maintenance of genome sequence integrity in long- and short-lived rodent species

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Chromosome Instability, Aging and Brain Diseases

Iourov, I. Y., Yurov, Y. B., Vorsanova, S. G., & Kutsev, S. I. (2021) · Cells · doi:10.3390/cells10051256 · Cited by 52

The complex interplay between aging and cancer

Trastus, L. A., & di Fagagna, F. D. (2025) · Nature Aging · doi:10.1038/s43587-025-00827-z · Cited by 56

mRNA Vaccines: Why Is the Biology of Retroposition Ignored?

Domazet‐Lošo, T. (2022) · Genes · doi:10.3390/genes13050719 · Cited by 47

The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks

Pereira, Q. C., dos Santos, T. W., Fortunato, I. M., & Ribeiro, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065508 · Cited by 51

Chromosome Instability in the Neurodegenerating Brain

Yurov, Y. B., Vorsanova, S. G., & Iourov, I. Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00892 · Cited by 45

LRRC37B Is a Species-Specific Regulator of Voltage-Gated Channels and Excitability in Human Cortical Neurons

Libé‐Philippot, B., Lejeune, A., Wierda, K. D. B., Louros, N. N., Erkol, E., Vlaeminck, I., Beckers, S., Gaspariunaite, V., Bilheu, A., Konstantoulea, K., et al. (2022) · Cell · doi:10.1016/j.cell.2023.11.028 · Cited by 44

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina, E., Shaposhnikov, M. V., & Moskalev, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124484 · Cited by 42

Mutations in normal tissues—some diagnostic and clinical implications

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The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration

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The link between Mitochondria and Sarcopenia

Kamarulzaman, N. T., & Makpol, S. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01062-7 · Cited by 33

De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas

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Genomic patterns of transcription–replication interactions in mouse primary B cells

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Inheritance of somatic mutations by animal offspring

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Hallmarks of aging: A user’s guide for comparative biologists

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Somatic mutation that affects transcription factor binding upstream of CD55 in the temporal cortex of a late-onset Alzheimer disease patient

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An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

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Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging

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Illegitimate and Repeated Genomic Integration of Cell-Free Chromatin in the Aetiology of Somatic Mosaicism, Ageing, Chronic Diseases and Cancer

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Cytopostgenomics: What is it and how does it work?

Iourov, I. Y. (2019) · Current Genomics · doi:10.2174/138920292002190422120524 · Cited by 21

Causes and Consequences of Genome Instability in Psychiatric and Neurodegenerative Diseases

Iourov, I. Y., Vorsanova, S. G., Куринная, О. С., Zelenova, M. A., Vasin, K. S., & Yurov, Y. B. (2021) · Molecular Biology · doi:10.1134/s0026893321010155 · Cited by 20

Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions

Proshkina, E., Solovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2020) · Molecular Biology · doi:10.1134/s0026893320060096 · Cited by 21

Challenges of proving a causal role of somatic mutations in the aging process

Franco, I., Revêchon, G., & Eriksson, M. (2022) · Aging Cell · doi:10.1111/acel.13613 · Cited by 18

Germline burden of rare damaging variants negatively affects human healthspan and lifespan

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Nanomaterials with Glucose Oxidase-Mimicking Activity for Biomedical Applications

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Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции

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Somatic mosaicism in the diseased brain

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Somatic Mutation Analysis in Salix suchowensis Reveals Early-Segregated Cell Lineages

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Single-cell omics in tracing cellular heterogeneity of drug-induced liver injury: Technological landscape and prospective application

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Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers

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Healthy skeletal muscle aging: The role of satellite cells, somatic mutations and exercise

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Antimutagenic Activity as a Criterion of Potential Probiotic Properties

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In silico study of heterogeneous tumour-derived organoid response to CAR T-cell therapy

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Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease

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Причины и последствия геномной нестабильности при психических и нейродегенеративных заболеваниях

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Arginine Depletion in Human Cancers

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Single-cell sequencing of the small and AT-skewed genome of malaria parasites

Liu, S., Huckaby, A. C., Brown, A. C., Moore, C. C., Burbulis, I. E., McConnell, M. J., & Güler, J. L. (2021) · Genome Medicine · doi:10.1186/s13073-021-00889-9 · Cited by 10

Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi

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The applicability of interphase chromosome-specific multicolor banding (ICS-MCB) for studying neurodevelopmental and neurodegenerative disorders

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Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster

Александровна, Ю. Е. (2020) · Radiation and Environmental Biophysics · doi:10.1007/s00411-020-00833-2 · Cited by 11

Cytogenomic landscape of the human brain

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Chromosome instability and aneuploidy in the mammalian brain

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Chlorpyrifos induces genotoxic effects in human leukocytes in vitro at low concentrations

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FISH-Based Analysis of Mosaic Aneuploidy and Chromosome Instability for Investigating Molecular and Cellular Mechanisms of Disease

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Evolution, Chance, and Aging

Frankel, S. A., & Rogina, B. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.733184 · Cited by 8

Biological Restraints on Indefinite SurvivalPreprint

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Genetic aspects of the oxidative phosphorylation dysfunction in dilated cardiomyopathy

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Exploring the Relationship Between Gene Expression and Low-Frequency Somatic Mutations in Arabidopsis with Duplex Sequencing

Waneka, G., Pate, B., Monroe, J. G., & Sloan, D. B. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae213 · Cited by 14

COVID-19 and Aging-Related Genome (Chromosome) Instability in the Brain: Another Possible Time-Bomb of SARS-CoV-2 Infection

Iourov, I. Y., & Vorsanova, S. G. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.786264 · Cited by 6

Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression

Aedh, A. I., Al‐kuraishy, H. M., Shokr, M. M., Alruwaili, M., & Batiha, G. E. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112802 · Cited by 7

FISHing for Unstable Cellular Genomes in the Human Brain

Yurov, Y. B., Vorsanova, S. G., & Iourov, I. Y. (2019) · OBM Genetics · doi:10.21926/obm.genet.1902076 · Cited by 5

Postzygotic mutations and where to find them – Recent advances and future implications in the field of non-neoplastic somatic mosaicism

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Struggle within: evolution and ecology of somatic cell populations

Świątczak, B. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03931-6 · Cited by 4

Linear covariation between germline and somatic mutation rates across ciliates and mammals

Wang, G., Fu, L., Miao, W., & Zhang, J. (2025) · Current Biology · doi:10.1016/j.cub.2025.07.045 · Cited by 3

Reconstructing the lifelong history of cells and tissues via somatic mutation analysis

Faienza, S., Margaria, J. P., & Franco, I. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05946-9 · Cited by 4

Cas9‐orthologue‐mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences

Li, M., Zhao, Y., Xue, X., Zhong, J., Lin, J., Zhou, J., Yu, W., Chen, J., & Qiao, Y. (2023) · Biotechnology Journal · doi:10.1002/biot.202200533 · Cited by 3

Somatic mutations acquired during life: state of the art and implications for the kidney

Margaria, J. P., Faienza, S., & Franco, I. (2025) · Kidney International · doi:10.1016/j.kint.2024.10.036 · Cited by 5

Somatic Mutations in KEAP1-NRF2 Complex in Breast Cancer

Almeida, M., Ferreira, C. L., Tomé, R. M., Fonseca-Moutinho, J. A., Polónia, A., Ramalhinho, A. C., & Breitenfeld, L. (2024) · Cancers · doi:10.3390/cancers16132411 · Cited by 2

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestryPreprint

Natu, A., Dehankar, M. K., Pattni, R., Šuvakov, M., Olisov, D., Tomasini, L., Jang, Y., Huang, Y., Benito-Garragori, E., Hasenfeld, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.28.685157 · Cited by 2

Matters Arising: The Information Theory of Aging Has Not Been TestedPreprint

Timmons, J. A., & Brenner, C. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4509193 · Cited by 2

Characterization of nuclear DNA diversity in an individual Leymus chinensis

Yu, H., Ma, L., Zhao, Y., Naren, G., Wu, H., Sun, Y., Wu, L., & Zhang, L. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1157145 · Cited by 1

Somatic mutations impose an entropic upper bound on human lifespan

Efimov, E., Fedotov, V., Malaev, L. G., Khrameeva, E. E., & Kriukov, D. V. (2026) · npj Aging · doi:10.1038/s41514-026-00421-6 · Cited by 2

Unstable Genomes in the Human Brain: What Does It Mean for Personalized Psychiatry and Neurology

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Genome-Wide Characterization of Somatic Mutation Patterns in Cloned Dogs Reveals Implications for Neuronal Function, Tumorigenesis, and Aging

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