Vijg, Jan

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell

Wound Healing and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 2,045

The central role of DNA damage in the ageing process

Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. (2021) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 907

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 669

Increased cell-to-cell variation in gene expression in ageing mouse heart

Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 603

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 553

Evidence for a limit to human lifespan

Dong, X., Milholland, B., & Vijg, J. (2016) · Nature

Insurance, Mortality, Demography, Risk ManagementGenetics, Aging, and Longevity in Model Organisms

Cited by 495

Puzzles, promises and a cure for ageing

Vijg, J., & Campisi, J. (2008) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 407

DNA damage and ageing: new-age ideas for an age-old problem

Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 366

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 353

SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., et al. (2019) · Cell

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 353

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 315

Nuclear genomic instability and aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 275

Somatic mutations and aging: a re-evaluation

Vijg, J. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 243

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S., & Campisi, J. (2017) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 234

Do DNA Double-Strand Breaks Drive Aging?

White, R. R., & Vijg, J. (2016) · Molecular Cell

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 232

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

Zhang, L., Dong, X., Lee, M., Maslov, A. Y., Wang, T., & Vijg, J. (2019) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 222

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J. (1990) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 201

Genetics of Longevity and Aging

Vijg, J., & Suh, Y. (2005) · Annual Review of Medicine

Genetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

Cited by 142

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Huang, Z., Sun, S., Lee, M., Maslov, A. Y., Shi, M., Waldman, S., Marsh, A., Siddiqui, T., Dong, X., Peter, Y., et al. (2022) · Nature Genetics

Cancer Genomics and DiagnosticsSmoking Behavior and Cessation

Cited by 125

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

Brazhnik, K., Sun, S., Alani, O., Kinkhabwala, M., Wolkoff, A. W., Maslov, A. Y., Dong, X., & Vijg, J. (2020) · Science Advances

Genetics, Aging, and Longevity in Model OrganismsCancer Genomics and Diagnostics

Cited by 114

Mitochondrial DNA mutations and aging: devils in the details?

Khrapko, K., & Vijg, J. (2009) · Trends in Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 112

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

Zhang, L., & Vijg, J. (2018) · Annual Review of Genetics

Cancer Genomics and DiagnosticsGenetics, Aging, and Longevity in Model Organisms

Cited by 108

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

White, R. R., Milholland, B., de Bruin, A., Curran, S., Laberge, R.-M., van Steeg, H., Campisi, J., Maslov, A. Y., & Vijg, J. (2015) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 107