Cited by 204Ethics in Clinical ResearchEthics and bioethics in healthcareMedical and Health Sciences Research

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Informed Consent in Genomics and Genetic Research

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McGuire, Amy L., Beskow, Laura M.·2010·Annual Review of Genomics and Human Genetics

DOI 10.1146/annurev-genom-082509-141711PMC PMC3216676

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Abstract

There are several features of genetic and genomic research that challenge established norms of informed consent. In this paper, we discuss these challenges, explore specific elements of informed consent for genetic and genomic research conducted in the United States, and consider alternative consent models that have been proposed. All of these models attempt to balance the obligation to respect and protect research participants with the larger social interest in advancing beneficial research as quickly as possible.

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Authors: McGuire, A. L., & Beskow, L. M.
Affiliations: Baylor College of Medicine (US)
Duke University (US)
ORCID: McGuire, Amy L.
Beskow, Laura M.
Venue: Annual Review of Genomics and Human Genetics
Publisher: Annual Reviews
Published: 2010-09-01
Volume: 11
Issue: 1
Pages: 361-381
ISSN: 1527-8204 (ISSN-L)
1545-293X
DOI: 10.1146/annurev-genom-082509-141711
PMC: PMC3216676
OpenAlex: W2129706078
Cited by: 204
References: 91
Citations by year: 2026: 8 · 2025: 10 · 2024: 12 · 2023: 11 · 2022: 19 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 16 · 2013: 10 · 2012: 11
FWCI: 1.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Genomics and Human Genetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders: National Institutes of Health
National Human Genome Research Institute (R01HG004333, R01HG004853)
National Center for Research Resources (UL1RR024128)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
Social Sciences › Law › Medical and Health Sciences Research
Keywords: informed consent, genomic research, genetic research, research ethics, research participant protection, research participant autonomy
MeSH terms: Humans, Informed Consent, Specimen Handling, United States, Genetic Research

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