The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
How Bacterial Carbohydrates Influence the Adaptive Immune System
Abstract
The capsular polysaccharides (CPSs) of most pathogenic bacteria are T cell–independent antigens whose conjugation to carrier proteins evokes a carbohydrate-specific response eliciting T cell help. However, certain bacterial CPSs, known as zwitterionic polysaccharides (ZPSs), activate the adaptive immune system through processing by antigen-presenting cells and presentation by the major histocompatibility complex class II pathway to CD4+T cells. This discovery was the first mechanistic insight into how carbohydrates—a class of biological molecules previously thought to be T cell independent—can in fact activate T cells. Through their ability to activate CD4+T cells, ZPSs direct the cellular and physical maturation of the developing immune system. In this review, we explore the still-enigmatic relations between CPSs and the adaptive immune machinery at the cellular and molecular levels, and we discuss how new insights into the biological impact of ZPSs expand our concepts of the role of carbohydrates in microbial interactions with the adaptive immune system.
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Cites
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Self-citationA microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Self-citationPolysaccharide processing and presentation by the MHCII pathway
Cobb, B. A., Wang, Q., Tzianabos, A. O., & Kasper, D. L. (2004) · Cell · doi:10.1016/j.cell.2004.05.001 · Cited by 340
Haurum, J. S., Arsequell, G., Lellouch, A. C., Wong, S. Y., Dwek, R. A., McMichael, A. J., & Elliott, T. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.2.739 · Cited by 184
Pöllabauer, E. M., Petermann, R., & Ehrlich, H. J. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.005 · Cited by 58
Cited by
Bacterial Outer Membrane Vesicles: From Discovery to Applications
Sartorio, M. G., Pardue, E. J., Feldman, M. F., & Haurat, M. F. (2021) · Annual Review of Microbiology · doi:10.1146/annurev-micro-052821-031444 · Cited by 398
Avci, F. Y., Li, X., Tsuji, M., & Kasper, D. L. (2011) · Nature Medicine · doi:10.1038/nm.2535 · Cited by 366
Self-citationMethicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
Brown, S., Xia, G., Luhachack, L. G., Campbell, J., Meredith, T. C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J. E., Peschel, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209126109 · Cited by 290
Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules
Cress, B. F., Englaender, J. A., He, W., Kasper, D., Linhardt, R. J., & Koffas, M. A. G. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12056 · Cited by 282
“Owing to their antigenicity in mammals, most CPS structures elicit T lymphocyte-independent immune responses that induce IgM antibody production but fail to stimulate T-cell-dependent IgM-IgG switching, an important attribute to ensure long-lasting immunity (Weintraub, 2003; Avci & Kasper, 2010).”
BackgroundSelf-citationNatural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
Pifferi, C., Fuentes, R., & Fernández-Tejada, A. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-020-00244-3 · Cited by 265
Metadata
- Authors
- Avci, F. Y., & Kasper, D. L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 107-130
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2102502668
- Cited by
- 238
- References
- 5
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
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