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Cited by 290

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

Open access
Brown, Stephanie, Xia, Guoqing, Luhachack, Lyly G., Campbell, Jennifer, Meredith, Timothy C., Chen, Calvin, Winstel, Volker, Gekeler, Cordula, Irazoqui, Javier E., Peschel, Andreas, Walker, Suzanne·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1209126109
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Abstract

Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d -alanylation, α- O -GlcNAcylation, and β- O -GlcNAcylation. Here we describe the discovery and biochemical characterization of a unique glycosyltransferase, TarS, that attaches β- O -GlcNAc (β- O - N -acetyl- d -glucosamine) residues to S. aureus WTAs. We report that methicillin resistant S. aureus (MRSA) is sensitized to β-lactams upon tarS deletion. Unlike strains completely lacking WTAs, which are also sensitive to β-lactams, Δ tarS strains have no growth or cell division defects. Because neither α- O -GlcNAc nor β- O -Glucose modifications can confer resistance, the resistance phenotype requires a highly specific chemical modification of the WTA backbone, β- O -GlcNAc residues. These data suggest β- O -GlcNAcylated WTAs scaffold factors required for MRSA resistance. The β- O -GlcNAc transferase identified here, TarS, is a unique target for antimicrobials that sensitize MRSA to β-lactams.

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Metadata

Authors
Brown, S., Xia, G., Luhachack, L. G., Campbell, J., Meredith, T. C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J. E., Peschel, A., & Walker, S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-10
Volume
109
Issue
46
Pages
18909-18914
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1209126109
OpenAlex
W2000478943
Cited by
290
References
47
FWCI
9.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. https://app.cochat.ai/papers/10.1073/pnas.1209126109
The paper
Brown, S., Xia, G., Luhachack, L. G., Campbell, J., Meredith, T. C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J. E., Peschel, A., & Walker, S. (2012). Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1209126109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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