The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Properdin: Emerging Roles of a Pattern-Recognition Molecule
Abstract
Complement is an innate immune system that is a first line of defense against pathogens and facilitates elimination of apoptotic and injured cells. During complement activation, the complement convertases are assembled on target surfaces and initiate their proteolytic activities, a process that marks targets for phagocytosis and/or lysis. The complement alternative activation pathway has been implicated in a number of autoimmune conditions including arthritis and age-related macular degeneration. Properdin, a plasma component that is also released by activated neutrophils, is critical in the stabilization of alternative pathway convertases. Recently, it has been shown that properdin is also a pattern-recognition molecule that binds to certain microbial surfaces, apoptotic cells, and necrotic cells. Once bound to a surface, properdin can direct convertase formation and target uptake. New studies are now focusing on a role for properdin in inflammatory and autoimmune diseases. This review examines the new properdin findings and their implications.
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Cites
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
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Carroll, M. C. (2004) · Nature Immunology · doi:10.1038/ni1113 · Cited by 1,035
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Cited by
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
Complement System Part I – Molecular Mechanisms of Activation and Regulation
Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620
Overview of complement activation and regulation
Noris, M., & Remuzzi, G. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.08.001 · Cited by 864
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Ricklin, D., & Lambris, J. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203487 · Cited by 478
Complement control protein factor H: The good, the bad, and the inadequate
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Metadata
- Authors
- Kemper, C., Atkinson, J. P., & Hourcade, D. E.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 131-155
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2126890639
- Cited by
- 228
- References
- 5
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
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