The DOI matches its Crossref record; 200 of the 200 references it cites were found in a registry or an index.
Complement control protein factor H: The good, the bad, and the inadequate
Open accessAbstract
The complement system is an essential component of the innate immune system that participates in elimination of pathogens and altered host cells and comprises an essential link between the innate and adaptive immune system. Soluble and membrane-bound complement regulators protect cells and tissues from unintended complement-mediated injury. Complement factor H is a soluble complement regulator essential for controlling the alternative pathway in blood and on cell surfaces. Normal recognition of self cell markers (i.e. polyanions) and C3b/C3d fragments is necessary for factor H function. Inadequate recognition of host cell surfaces by factor H due to mutations and polymorphisms have been associated with complement-mediated tissue damage and disease. On the other hand, unwanted recognition of pathogens and altered self cells (i.e. cancer) by factor H is used as an immune evasion strategy. This review will focus on the current knowledge related to these versatile recognition properties of factor H.
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Cites
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Self-citationTHE ROLE OF COMPLEMENT AND COMPLEMENT RECEPTORS IN INDUCTION AND REGULATION OF IMMUNITY
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Cited by
Age related macular degeneration and drusen: Neuroinflammation in the retina
Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230
Sweet escape: Sialic acids in tumor immune evasion
Büll, C., den Brok, M. H., & Adema, G. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.005 · Cited by 158
Linnartz, B., Kopatz, J., Tenner, A. J., & Neumann, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3830-11.2012 · Cited by 134
Geis-Asteggiante, L., Belew, A. T., Clements, V. K., Edwards, N. J., Ostrand-Rosenberg, S., El-Sayed, N. M., & Fenselau, C. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00646 · Cited by 104
Hijacking Factor H for Complement Immune Evasion
Moore, S. R., Menon, S. S., Cortes, C., & Ferreira, V. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.602277 · Cited by 83
Metadata
- Authors
- Ferreira, V. P., Pangburn, M. K., & Cortés, C.
- Venue
- Molecular Immunology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 47
- Issue
- 13
- Pages
- 2187-2197
- ISSN
- 0161-5890 (ISSN-L)
- OpenAlex
- W2133876809
- Cited by
- 420
- References
- 200
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
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