The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Complement and Its Receptors: New Insights into Human Disease
Open accessAbstract
Although new activation and regulatory mechanisms are still being identified, the basic architecture of the complement system has been known for decades. Two major roles of complement are to control certain bacterial infections and to promote clearance of apoptotic cells. In addition, although inappropriate complement activation has long been proposed to cause tissue damage in human inflammatory and autoimmune diseases, whether this is indeed true has been uncertain. However, recent studies in humans, especially those using newly available biological therapeutics, have now clearly demonstrated the pathophysiologic importance of the complement system in several rare diseases. Beyond these conditions, recent genetic studies have strongly supported an injurious role for complement in a wide array of human inflammatory, degenerative, and autoimmune diseases. This review includes an overview of complement activation, regulatory, and effector mechanisms. It then focuses on new understandings gained from genetic studies, ex vivo analyses, therapeutic trials, and animal models as well as on new research opportunities.
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“Additional inducers of low-grade inflammation are nutrients and metabolites acting as DAMPs (e.g., free fatty acids, oxidized lipoproteins) and commensal bacteria representing a source of PAMPs [sometimes also described with the more global term microbe-associated molecular patterns (MAMPs), as they are not necessarily pathogenic] (189, 240, 244, 295, 329, 347).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [240]
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Cites
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Self-citation
Metadata
- Authors
- Holers, V. M.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Holers, V. Michael
- ORCID
- Holers, V. Michael
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 433-459
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2163243965
- Cited by
- 430
- References
- 152
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 33 · 2023: 27 · 2022: 39 · 2021: 48 · 2020: 46 · 2019: 42 · 2018: 34 · 2017: 40 · 2016: 36 · 2015: 27 · 2014: 10
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lupus Research Alliance
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI105717)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR051749)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- complement system, complement receptors, complement activation, complement regulation, efferocytosis, bacterial infection, inflammatory diseases, autoimmune disease, degenerative diseases, rare diseases, genetic research, complement therapeutics, tissue damage
- MeSH terms
- Animals, Carrier Proteins, Complement System Proteins, Complement Activation, Disease Models, Animal, Disease Susceptibility, Humans, Protein Binding, Receptors, Complement, Signal Transduction, Genetic Predisposition to Disease
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