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Cited by 96Cellular Mechanics and InteractionsT-cell and B-cell ImmunologyCell Adhesion Molecules Research

Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

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Hammer, John A., Wang, Jia C., Saeed, Mezida, Pedrosa, Antonio T.·2019·Annual Review of Immunology
DOI 10.1146/annurev-immunol-042718-041341PMC PMC8343269
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Abstract

The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.

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  • ARP2/3-mediated actin polymerization drives cell spreading at immunological synapses and shapes the complex architectures that enable efficient antigen presentation and lymphocyte activation.

    “ARP2/3-mediated actin polymerization drives cell spreading at immunological synapses and shapes the complex architectures that enable efficient antigen presentation and lymphocyte activation (Fig. 1e) [12, 22, 23].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [23]

    The dSMAC section (page unavailable) says Arp2/3 creates a branched actin network that drives T-cell spreading at the immunological synapse. The TCR microcluster signaling section (page unavailable) links that network’s flow to T-cell signaling. The paper does not establish the further claim that these architectures enable efficient antigen presentation; its account focuses on the T-cell side of the synapse. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • HEM1-deficient T cells fail to properly integrate antigen signals and fully activate because T cell immune synapses are highly dependent on ARP2/3-mediated F-actin polymerization.

    “Because T cell immune synapses are highly dependent on ARP2/3-mediated F-actin polymerization [12, 22, 23, 37], HEM1-deficient T cells fail to properly integrate antigen signals and fully activate.”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [23]

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Cited by

Sorted by citations

Authors
Hammer, J. A., Wang, J. C., Saeed, M., & Pedrosa, A. T.
Affiliations
  • National Institutes of Health (US)
  • Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA;
Corresponding author
Hammer, John A.
ORCID
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2019-04-26
Volume
37
Issue
1
Pages
201-224
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev-immunol-042718-041341
PMC
PMC8343269
OpenAlex
W2906607503
Cited by
96
References
0
Citations by year
2026: 3 · 2025: 13 · 2024: 15 · 2023: 10 · 2022: 17 · 2021: 20 · 2020: 11 · 2019: 7
FWCI
1.07
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (ZIAHL006121)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
immunological synapse, actin cytoskeleton, actomyosin, T cell activation, antigen-presenting cells, cytoskeletal dynamics, T cell signaling
MeSH terms
Actins, Actomyosin, Animals, Antigen-Presenting Cells, Cytoskeleton, Humans, Lymphocyte Activation, T-Lymphocytes, Antigen Presentation, Immunological Synapses

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