The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga
Abstract
Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than traditional drugs to cause serious gastrointestinal adverse effects, but predispose to adverse cardiovascular events, such as heart failure, myocardial infarction, and stroke. Evidence from human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials indicates that this is consequent to suppression of COX-2-dependent cardioprotective prostagladins, particularly prostacyclin. Lessons drawn from how this saga unfolded are relevant to how we approach drug surveillance and regulation, integrate diversifed forms of information and might pursue a more personalized approach to drug efficacy and risk.
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Cites
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050493 · Cited by 2,519
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Meta-analysis of Cyclooxygenase-2 Inhibitors and Their Effects on Blood Pressure
(2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.5.ioi50013 · Cited by 329
Nociception in cyclooxygenase isozyme-deficient mice
Ballou, L. R., Botting, R. M., Goorha, S., Zhang, J., & Vane, J. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180319297 · Cited by 205
Expression of Concern Reaffirmed
Curfman, G. D., Morrissey, S., & Drazen, J. M. (2006) · New England Journal of Medicine · doi:10.1056/nejme068054 · Cited by 109
Cited by
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Bindu, S., Mazumder, S., & Bandyopadhyay, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114147 · Cited by 1,920
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis
Smith, W. L., Urade, Y., & Jakobsson, P.-J. (2011) · Chemical Reviews · doi:10.1021/cr2002992 · Cited by 503
Cardiovascular effects and safety of (non-aspirin) NSAIDs
Schjerning, A.-M., McGettigan, P., & Gislason, G. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0366-z · Cited by 387
Schmidt, M., Lamberts, M., Olsen, A.-M. S., Fosbøll, E., Niessner, A., Tamargo, J., Rosano, G., Agewall, S., Kaski, J. C., Kjeldsen, K., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv505 · Cited by 164
Metadata
- Authors
- Grosser, T., Yu, Y., & FitzGerald, G. A.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2010-02-01
- Volume
- 61
- Issue
- 1
- Pages
- 17-33
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2168581452
- Cited by
- 232
- References
- 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grosser, T., Yu, Y., & FitzGerald, G. A. (2010). Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine. https://doi.org/10.1146/annurev-med-011209-153129
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
