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Cited by 284Opioid Use Disorder TreatmentPain Management and Opioid UseAnesthesia and Pain Management

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Use and Misuse of Opioids in Chronic Pain

Volkow, Nora, Benveniste, Helene, McLellan, A. Thomas·2018·Annual Review of Medicine
DOI 10.1146/annurev-med-011817-044739
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Abstract

The prescribing of opioid analgesics for pain management-particularly for management of chronic noncancer pain (CNCP)-has increased more than fourfold in the United States since the mid-1990s. Yet there is mounting evidence that opioids have only limited effectiveness in the management of CNCP, and the increased availability of prescribed opioids has contributed to upsurges in opioid-related addiction cases and overdose deaths. These concerns have led to critical revisiting and modification of prior pain management practices (e.g., guidelines from the Centers for Disease Control and Prevention), but the much-needed changes in clinical practice will be facilitated by a better understanding of the pharmacology and behavioral effects of opioids that underlie both their therapeutic effects (analgesia) and their adverse effects (addiction and overdose). With these goals in mind, this review first presents an overview of the contemporary problems associated with opioid management of CNCP and the related public health issues of opioid diversion, overdose, and addiction. It then discusses the pharmacology underlying the therapeutic and main adverse effects of opioids and its implications for clinical management of CNCP within the framework of recent clinical guidelines for prescribing opioids in the management of CNCP.

Overview

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Registry

Crossref · 10.1146/annurev-med-011817-044739

Cites

84 of 84 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 84 references

Research works printed but not linked: 13

  1. Centers for Disease Control and Prevention., 2001, Morb. Mortal. Wkly. Rep., 50, 120
  2. Centers for Disease Control and Prevention., 2011, Morb. Mortal. Wkly. Rep., 60, 1487
  3. Deshpande A, 2007, Cochrane Database Syst. Rev., 3, CD004959
  4. Hollingshead J, 2006, Cochrane Database Syst. Rev, 3, CD003726
  5. Lee BH, 2013, Pain Physician, 16, E217
  6. Derry S, 2012, Cochrane Database Syst. Rev., 3, CD008244
  7. Linde K, 2016, Cochrane Database Syst. Rev., 4, CD007587
  8. Centers for Disease Control and Prevention., 2013, Morb. Mortal. Wkly. Rep., 62, 234
  9. Jones CM, 2014, Morb. Mortal. Wkly. Rep, 63, 881
  10. Wheeler E, 2015, Morb. Mortal. Wkly. Rep, 64, 631
  11. Office of the Surgeon General., 2016, Facing Addiction in America. The Surgeon General's Report on Alcohol, Drugs, and Health.
  12. Geneen LJ, 2017, Cochrane Database Syst. Rev., 1, CD011279
  13. O'Malley PG, 1999, J. Fam. Pract., 48, 980

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Metadata

Authors
Volkow, N., Benveniste, H., & McLellan, A. T.
Affiliations
  • National Institute on Drug Abuse (US)
  • Yale University (US)
  • Treatment Research Institute (US)
ORCID
Venue
Annual Review of Medicine
Publisher
Annual Reviews
Published
2018-01-29
Volume
69
Issue
1
Pages
451-465
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
DOI
10.1146/annurev-med-011817-044739
OpenAlex
W2587222353
Cited by
279
References
84
Citations by year
2026: 14 · 2025: 28 · 2024: 40 · 2023: 30 · 2022: 38 · 2021: 44 · 2020: 27 · 2019: 40 · 2018: 17
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Keywords
opioids, chronic non-cancer pain, opioid prescribing, opioid use disorder, opioid overdose, opioid diversion, opioid pharmacology, opioid side effects, opioid analgesia, pain management
MeSH terms
Analgesics, Opioid, Humans, Opioid-Related Disorders, Chronic Pain, Pain Management, Drug Overdose, Prescription Drug Misuse, Prescription Drug Diversion

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