Cited by 79Opioid Use Disorder TreatmentPain Management and Opioid UseMusculoskeletal pain and rehabilitation

Chronic pain treatment with opioid analgesics: benefits versus harms of long-term therapy

Sehgal, Nalini, Colson, James, Smith, Howard S·2013·Expert Review of Neurotherapeutics

Abstract

Chronic non-cancer pain (CNCP) is a disabling chronic condition with a high prevalence rate around the world. Opioids are routinely prescribed for treatment of chronic pain (CP). In the past two decades there has been a massive increase in the number of opioid prescriptions, prescribed daily opioid doses and overall opioid availability. Many more patients with CNCP receive high doses of long-acting opioids on a long-term basis. Yet CP and related disability rates remain high, and majority of the patients with CNCP are dissatisfied with their treatments. Intersecting with the upward trajectory in opioid use are the increasing trends in opioid related adverse effects, especially prescription drug abuse, addiction and overdose deaths. This complex situation raises questions on the relevance of opioid therapy in the treatment of CNCP. This article reviews current evidence on opioid effectiveness, the benefits and harms of long-term therapy in CNCP.

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Crossref · 10.1586/14737175.2013.846517

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145 of 145 references verified0 citation errors · 0 not checkable

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Authors
Sehgal, N., Colson, J., & Smith, H. S.
Affiliations
  • University of Wisconsin–Madison (US)
  • West Virginia University Hospitals (US)
  • Albany Medical College (US)
Corresponding author
Sehgal, Nalini
Venue
Expert Review of Neurotherapeutics
Published
2013-11
Volume
13
Issue
11
Pages
1201-1220
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
OpenAlex
W2162578564
Cited by
79
References
145
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 11 · 2015: 11 · 2014: 5
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
chronic non-cancer pain, opioid analgesics, long-term opioid therapy, long-acting opioids, opioid-related harms, prescription drug misuse, opioid use disorder, opioid overdose deaths, opioid prescribing trends, treatment effectiveness
MeSH terms
Analgesics, Opioid, Humans, Opioid-Related Disorders, Time Factors, Randomized Controlled Trials as Topic, Treatment Outcome, Risk Assessment, Chronic Pain, Pain Management

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