Cited by 111Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

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Gandy, Sam, DeKosky, Steven T.·2013·Annual Review of Medicine

DOI 10.1146/annurev-med-092611-084441PMC PMC3625402

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Abstract

Alzheimer's disease (AD) is the major cause of late-life brain failure. In the past 25 years, autosomal dominant forms of AD were found to be primariy attributable to mutations in one of two presenilins, polytopic proteins that contain the catalytic site of the γ-secretase protease that releases the amyloid beta (Aβ) peptide. Some familial AD is also due to mutations in the amyloid precursor protein (APP), but recently a mutation in APP was discovered that reduces Aβ generation and is protective against AD, further implicating amyloid metabolism. Prion-like seeding of amyloid fibrils and neurofibrillary tangles has been invoked to explain the stereotypical spread of AD within the brain. Treatment trials with anti-Aβ antibodies have shown target engagement, if not significant treatment effects. Attention is increasingly focused on presymptomatic intervention, because Aβ mismetabolism begins up to 25 years before symptoms begin. AD trials deriving from new biological information involve extraordinary international collaboration and may hold the best hope for success in the fight against AD.

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RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons
Liang, Q., Fujita, R., Yamashita, T., Angulo, S. L., Rhinn, H., Rhee, D. B., Doege, C. A., Chau, L., Aubry, L., Vanti, W. B., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.007 · Cited by 231
Retracted
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Revising the definition of Alzheimer's disease: a new lexicon
Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N. C., Galasko, D., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70223-4 · Cited by 1,869
Self-citation
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857
Transmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803

Show all 100 references

Research works printed but not linked: 1

10.1001/jama.1997.03550020068040 · DOI

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Gu, H. (2013) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000e115 · Cited by 2
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Yang, Z.-Y., Li, J., Xiao, L., Mou, L., Cai, Y., Huang, H., Luo, X., & Yan, X. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12271 · Cited by 2
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Chen, R., Gao, H., Zhu, T., Zheng, N., Jin, Y., Li, M., & Lu, Z. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05227-3 · Cited by 1
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Self-citation
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Chaudhuri, I., & Das, S. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251317955 · Cited by 2
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Malmsten, L. (2014) · Figshare
Alzheimer’s Disease and white matter
Filley, C. M. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781139548878.016

Authors: Gandy, S., & DeKosky, S. T.
Affiliations: James J. Peters VA Medical Center (US)
University of Virginia (US)
ORCID: Gandy, Sam
DeKosky, Steven T.
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 2013-01-14
Volume: 64
Issue: 1
Pages: 367-383
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev-med-092611-084441
PMC: PMC3625402
OpenAlex: W2135220503
Cited by: 110
References: 100
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 2 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 17 · 2014: 17 · 2013: 13
FWCI: 2.09
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 BX000348)
GlaxoSmithKline
National Institute on Aging (AG 05-133, P50 AG 05138, P01AG025204, P50AG005133, P50AG005138, AG025204, U19AG010483)
National Institute of Neurological Disorders and Stroke (R01NS075685)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, presenilin mutations, amyloid-beta, gamma-secretase, amyloid precursor protein, familial Alzheimer's disease, anti-amyloid antibodies, prion-like seeding, neurofibrillary tangles, amyloid metabolism
MeSH terms: Alzheimer Disease, Brain, DNA, Humans, Immunologic Factors, Mutation, Global Health, Incidence, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Practice Guidelines as Topic

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Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

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