CoChat
Sign Up
Cited by 29Bacterial Genetics and BiotechnologyBiochemical and Structural CharacterizationGene Regulatory Network Analysis

The DOI matches its Crossref record; its reference list is not available.

A Life in Bacillus subtilis Signal Transduction

Open access
Hoch, James A.·2017·Annual Review of Microbiology
DOI 10.1146/annurev-micro-030117-020355
Open this paper in CoChat — free accountOpen PDF

Abstract

This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins evolve interaction specificity and to identification of interaction surfaces by statistical physics. This is about how the people in my laboratory accomplished this feat; without them little would have been done.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1146/annurev-micro-030117-020355

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 100 · Cited by 29

Research works printed but not linked: 101

  1. 10.1016/0161-5890(82)90323-6 · DOI
  2. Allen RW, 1987, J. Biol. Chem., 262, 649, 10.1016/S0021-9258(19)75833-5 · DOI
  3. Anagnostopoulos C, 1961, J. Bacteriol., 81, 741, 10.1128/jb.81.5.741-746.1961 · DOI
  4. 10.1073/pnas.95.9.5317 · DOI
  5. 10.1073/pnas.83.16.5943 · DOI
  6. 10.1016/0092-8674(91)90238-T · DOI
  7. 10.1128/jb.166.2.412-416.1986 · DOI
  8. 10.1007/BF01576975 · DOI
  9. 10.1073/pnas.1201301109 · DOI
  10. 10.1046/j.1365-2958.1997.4491805.x · DOI
  11. Fabret C, 1998, J. Bacteriol., 180, 6375, 10.1128/JB.180.23.6375-6383.1998 · DOI
  12. 10.1002/pro.5560040915 · DOI
  13. Ferrari E, 1981, J. Bacteriol., 146, 430, 10.1128/jb.146.1.430-432.1981 · DOI
  14. Ferrari FA, 1982, J. Bacteriol., 152, 780, 10.1128/jb.152.2.780-785.1982 · DOI
  15. Ferrari FA, 1982, J. Bacteriol., 152, 809, 10.1128/jb.152.2.809-814.1982 · DOI
  16. Ferrari FA, 1985, J. Bacteriol., 161, 556, 10.1128/jb.161.2.556-562.1985 · DOI
  17. Ferrari FA, 1985, Molecular Biology of Microbial Differentiation, 8
  18. 10.1073/pnas.82.9.2647 · DOI
  19. 10.1111/j.1365-2958.2010.07464.x · DOI
  20. 10.1111/j.1365-2958.2008.06308.x · DOI
  21. Gay P, 1983, J. Bacteriol., 153, 1424, 10.1128/jb.153.3.1424-1431.1983 · DOI
  22. 10.1073/pnas.79.19.6065 · DOI
  23. 10.1128/jb.170.1.296-300.1988 · DOI
  24. Higerd TB, 1972, J. Bacteriol., 112, 1026, 10.1128/jb.112.2.1026-1028.1972 · DOI
  25. Hoch JA, 1971, J. Bacteriol., 105, 896, 10.1128/jb.105.3.896-901.1971 · DOI
  26. 10.1016/S0065-2660(08)60437-X · DOI
  27. Hoch JA, 1978, J. Bacteriol., 133, 265, 10.1128/jb.133.1.265-269.1978 · DOI
  28. Hoch JA, 1975, J. Immunol., 114, 1638, 10.4049/jimmunol.114.5.1638 · DOI
  29. Hoch JA, 1973, Genetics, 73, 215, 10.1093/genetics/73.2.215 · DOI
  30. Hoch JA, 1973, J. Bacteriol., 116, 59, 10.1128/jb.116.1.59-66.1973 · DOI
  31. 10.1128/JB.183.17.4941-4949.2001 · DOI
  32. Hranueli D, 1974, J. Bacteriol., 119, 684, 10.1128/jb.119.3.684-690.1974 · DOI
  33. 10.1074/jbc.M201086200 · DOI
  34. 10.1016/j.jmb.2010.10.047 · DOI
  35. Kallio PT, 1991, J. Biol. Chem., 266, 13411, 10.1016/S0021-9258(18)98855-1 · DOI
  36. 10.1038/36786 · DOI · Paper page
  37. Lepesant-Kejzlarova J, 1975, J. Bacteriol., 121, 823, 10.1128/jb.121.3.823-834.1975 · DOI
  38. 10.1038/227910a0 · DOI
  39. 10.1016/S0076-6879(10)71002-8 · DOI
  40. 10.1016/S0969-2126(96)00074-3 · DOI
  41. Moran CPJ, 1980, J. Bacteriol., 142, 331, 10.1128/jb.142.1.331-334.1980 · DOI
  42. 10.1128/jb.174.13.4361-4373.1992 · DOI
  43. 10.1128/jb.174.13.4374-4383.1992 · DOI
  44. 10.1111/j.1365-2958.2004.04196.x · DOI
  45. 10.1128/JB.187.21.7444-7459.2005 · DOI
  46. 10.1073/pnas.83.16.5909 · DOI
  47. 10.1073/pnas.85.15.5492 · DOI
  48. 10.1073/pnas.91.5.1756 · DOI
  49. 10.1016/j.str.2014.08.018 · DOI
  50. Ordal GW, 1983, J. Bacteriol., 154, 1088, 10.1128/jb.154.3.1088-1097.1983 · DOI
  51. 10.1007/BF01572322 · DOI
  52. 10.1073/pnas.94.16.8612 · DOI
  53. 10.1046/j.1365-2958.2001.02611.x · DOI
  54. 10.1371/journal.pbio.1001516 · DOI
  55. 10.1016/S0196-9781(01)00490-9 · DOI
  56. 10.1128/jb.171.11.6187-6196.1989 · DOI
  57. 10.1016/0092-8674(94)90035-3 · DOI
  58. 10.1111/j.1365-2958.1991.tb01838.x · DOI
  59. 10.1111/j.1365-2958.1987.tb00536.x · DOI
  60. 10.1128/jb.170.6.2560-2567.1988 · DOI
  61. 10.1128/jb.173.8.2514-2520.1991 · DOI
  62. 10.1073/pnas.93.4.1549 · DOI
  63. 10.1111/j.1365-2958.1988.tb00079.x · DOI
  64. 10.1016/0378-1119(91)90368-L · DOI
  65. Piggot PJ, 1973, J. Bacteriol., 114, 1241, 10.1128/jb.114.3.1241-1253.1973 · DOI
  66. 10.2741/913 · DOI
  67. 10.1089/omi.1.1997.2.103 · DOI
  68. Rutberg B, 1970, J. Bacteriol., 104, 826, 10.1128/jb.104.2.826-833.1970 · DOI
  69. 10.1128/JB.01937-06 · DOI
  70. 10.1016/S0076-6879(10)71003-X · DOI
  71. 10.1073/pnas.0912100106 · DOI
  72. Shabbaz M, 1987, J. Biol. Chem., 262, 16412, 10.1016/S0021-9258(18)49271-X · DOI
  73. 10.1101/gad.10.16.2014 · DOI
  74. 10.1073/pnas.44.10.1072 · DOI
  75. 10.1111/j.1365-2958.2011.07608.x · DOI
  76. 10.1073/pnas.82.23.7989 · DOI
  77. 10.1111/j.1365-2958.1993.tb01125.x · DOI
  78. 10.1002/j.1460-2075.1989.tb03546.x · DOI
  79. 10.1073/pnas.87.5.1801 · DOI
  80. 10.1101/gad.3.2.141 · DOI
  81. 10.1073/pnas.0800247105 · DOI
  82. 10.1128/JB.01936-06 · DOI
  83. 10.1128/JB.187.15.5419-5426.2005 · DOI
  84. 10.1110/ps.052064406 · DOI
  85. 10.1073/pnas.82.21.7260 · DOI
  86. 10.1111/j.1365-2958.1993.tb01204.x · DOI
  87. Trowsdale J, 1978, J. Bacteriol., 135, 99, 10.1128/jb.135.1.99-113.1978 · DOI
  88. 10.1007/BF00267691 · DOI
  89. Trowsdale J, 1982, Oncodevelopmental Biol. Med., 3, 391
  90. 10.1006/jmbi.1997.1226 · DOI
  91. 10.1074/jbc.273.37.23849 · DOI
  92. 10.1016/S1097-2765(00)80148-3 · DOI
  93. 10.1038/81999 · DOI
  94. 10.1101/gad.11.19.2569 · DOI
  95. 10.1073/pnas.0805923106 · DOI · Paper page
  96. 10.1016/S0076-6879(06)22004-4 · DOI
  97. 10.1016/S0006-291X(88)80005-6 · DOI
  98. Yamaguchi M, 1988, J. Biol. Chem., 263, 2761, 10.1016/S0021-9258(18)69134-3 · DOI
  99. 10.1021/bi9729615 · DOI
  100. 10.1016/S0969-2126(00)00174-X · DOI
  101. 10.1016/S0969-2126(02)00803-1 · DOI

Metadata

Authors
Hoch, J. A.
Affiliations
Scripps Research Institute (US)
Corresponding author
Hoch, James A.
Venue
Annual Review of Microbiology
Publisher
Annual Reviews
Published
2017-09-08
Volume
71
Issue
1
Pages
1-19
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
DOI
10.1146/annurev-micro-030117-020355
OpenAlex
W2617383549
Cited by
29
References
100
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1
FWCI
0.18
Type
journal article
Language
en
Open access
Licence
www.annualreviews.org/licenses/tdm (tdm)
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
Bacillus subtilis, signal transduction, sporulation initiation, two-component systems, protein-protein interaction specificity, protein evolution, interaction surfaces, statistical physics, structural biology, bacterial genetics
MeSH terms
Adaptation, Physiological, Bacillus subtilis, Signal Transduction, Gene Expression Regulation, Bacterial, History, 20th Century, History, 21st Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A Life in Bacillus subtilis Signal Transduction. https://app.cochat.ai/papers/10.1146/annurev-micro-030117-020355
The paper
Hoch, J. A. (2017). A Life in Bacillus subtilis Signal Transduction. Annual Review of Microbiology. https://doi.org/10.1146/annurev-micro-030117-020355