The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
The Glyoxylate Shunt, 60 Years On
Abstract
2017 marks the 60th anniversary of Krebs’ seminal paper on the glyoxylate shunt (and coincidentally, also the 80th anniversary of his discovery of the citric acid cycle). Sixty years on, we have witnessed substantial developments in our understanding of how flux is partitioned between the glyoxylate shunt and the oxidative decarboxylation steps of the citric acid cycle. The last decade has shown us that the beautifully elegant textbook mechanism that regulates carbon flux through the shunt in E. coli is an oversimplification of the situation in many other bacteria. The aim of this review is to assess how this new knowledge is impacting our understanding of flux control at the TCA cycle/glyoxylate shunt branch point in a wider range of genera, and to summarize recent findings implicating a role for the glyoxylate shunt in cellular functions other than metabolism.
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“For instance, the glyoxylate shunt GS is an anaplerotic reaction of the tricarboxylic acid TCA cycle developed in numerous species, which bypasses two NADH-generating steps [194].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [194]
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Cites
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Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622534 · Cited by 284
Phage-specific metabolic reprogramming of virocells
Howard‐Varona, C., Lindback, M., Bastien, G. E., Solonenko, N., Zayed, A. A., Jang, H. B., Andreopoulos, B., Brewer, H. M., del Rio, T. G., Adkins, J., et al. (2020) · The ISME Journal · doi:10.1038/s41396-019-0580-z · Cited by 239
Immunometabolic crosstalk during bacterial infection
Rosenberg, G., Riquelme, S. A., Prince, A. S., & Avraham, R. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01080-5 · Cited by 152
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Metadata
- Authors
- Dolan, S. K., & Welch, M.
- Affiliations
- University of Cambridge (GB)
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2018-09-08
- Volume
- 72
- Issue
- 1
- Pages
- 309-330
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2892337114
- Cited by
- 180
- References
- 85
- Citations by year
- 2026: 33 · 2025: 24 · 2024: 19 · 2023: 22 · 2022: 20 · 2021: 25 · 2020: 27 · 2019: 9 · 2018: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/R005435/1, BB/M019411/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- glyoxylate cycle, TCA cycle, carbon flux partitioning, oxidative decarboxylation, flux control, Escherichia coli, bacterial metabolism
- MeSH terms
- Carbon, Escherichia coli, Glyoxylates, Metabolic Networks and Pathways, Metabolic Flux Analysis
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