Cited by 284Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsBacterial Genetics and Biotechnology

Reactive oxygen species in pathogen clearance: The killing mechanisms, the adaption response, and the side effects

Open access
Li, Hao, Zhou, Xuedong, Huang, Yuyao, Liao, Binyou, Cheng, Lei, Ren, Biao·2021·Frontiers in Microbiology

Abstract

Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm. In the case of bacterial pathogens, the examples of some certain pathogens thriving under ROS conditions prompt us to focus on the adaption mechanism that pathogens evolve to cope with ROS. Based on these, we here summarized the mechanisms of ROS-mediated killing of either antibiotics or the host, the examples of bacterial adaption that successful pathogens evolved to defend or thrive under ROS conditions, and the potential side effects of ROS in pathogen clearance. A brief section for new antibacterial strategies centered around ROS was also addressed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fmicb.2020.622534

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the recognition and response process of phagocytosis, reactive oxygen species ROS and reactive nitrogen species RNS are produced.

    “In the recognition and response process of phagocytosis, reactive oxygen species ROS and reactive nitrogen species RNS are produced [5].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [5]

  • Under non-lethal levels of ROS, certain pathogens have evolved mechanisms to adapt and thrive, and may even use ROS as a cornerstone for increasing tolerance and resistance to antibiotics.

    “However, they are a double-edged sword and must be regulated with care, as under non-lethal levels of ROS, certain pathogens have evolved mechanisms to adapt and thrive, and may even use ROS as a cornerstone for increasing tolerance and resistance to antibiotics.”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [5]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B.
Affiliations
Sichuan University (CN)
Corresponding author
  • Cheng, Lei
  • Ren, Biao
Venue
Frontiers in Microbiology
Published
2021-02-04
Volume
11
Pages
622534-622534
ISSN
1664-302X (ISSN-L)
OpenAlex
W4206764679
Cited by
284
References
92
Citations by year
2026: 39 · 2025: 79 · 2024: 65 · 2023: 52 · 2022: 41 · 2021: 8
FWCI
4.35
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China
  • Applied Basic Research Program of Sichuan Province
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
reactive oxygen species, pathogen clearance, antibacterial strategies, pathogenic bacteria

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review