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Activating Transcription in Bacteria
Abstract
Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in order to activate transcription in response to growth signals or environmental cues. Activation can be due to factors that interact at specific promoters, thereby increasing transcription directed by these promoters. We examine the range of architectures found at activator-dependent promoters and outline the mechanisms by which input from different factors is integrated. Alternatively, activation can be due to factors that interact with RNA polymerase and change its preferences for target promoters. We summarize the different mechanistic options for activation that are focused directly on RNA polymerase.
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Cited by
Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180
The Evolution of Function in the DNA-Binding Domain of the CRP/FNR Family
Krishnaswamy, M., & Seshasayee, A. S. N. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf182 · Cited by 3
Metadata
- Authors
- Lee, D. J., Minchin, S. D., & Busby, S. J. W.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2012-10-13
- Volume
- 66
- Issue
- 1
- Pages
- 125-152
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2135034797
- Cited by
- 267
- References
- 0
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Activating Transcription in Bacteria. https://app.cochat.ai/papers/10.1146/annurev-micro-092611-150012
- The paper
- Lee, D. J., Minchin, S. D., & Busby, S. J. W. (2012). Activating Transcription in Bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev-micro-092611-150012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
