The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance
Abstract
Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance. Yeasts are no exception. They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR) and in the cellular efflux of a wide variety of drugs. The PDR transporters Pdr5p of Saccharomyces cerevisiae and Cdr1p of Candida albicans are important members of this PDR subfamily, which comprises up to 10 phylogenetic clusters in fungi. Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters.
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“Pdr5 transports a diverse set of structurally unrelated compounds including azoles, cycloheximide, and rhodamines15.”
From Dual action antifungal small molecule modulates multidrug efflux and TOR signaling (2016) · cites this paper as [15]
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Cites
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Cited by
Sorted by citations
Mechanisms of Antifungal Drug Resistance
Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647
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Berkow, E., & Lockhart, S. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s118892 · Cited by 542
Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies
Catalano, A., Iacopetta, D., Ceramella, J., Scumaci, D., Giuzio, F., Saturnino, C., Aquaro, S., Rosano, C., & Sinicropi, M. S. (2022) · Molecules · doi:10.3390/molecules27030616 · Cited by 450
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Emerging Threats in Antifungal-Resistant Fungal Pathogens
Sanglard, D. (2016) · Frontiers in Medicine · doi:10.3389/fmed.2016.00011 · Cited by 436
Metadata
- Authors
- Prasad, R., & Goffeau, A.
- Affiliations
- Jawaharlal Nehru University (IN)
- Institut des Sciences de la Vie, Université Catholique de Louvain, Louvain-la-Neuve, 1349 Belgium;
- ORCID
- Prasad, Rajendra
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2012-10-13
- Volume
- 66
- Issue
- 1
- Pages
- 39-63
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2101491044
- Cited by
- 221
- References
- 111
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 17 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 12 · 2017: 17 · 2016: 25 · 2015: 21 · 2014: 18 · 2013: 20 · 2012: 4
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- ABC transporters, multidrug resistance, pleiotropic drug resistance, Pdr5p, Cdr1p, Saccharomyces cerevisiae, Candida albicans, drug efflux, ABC exporters
- MeSH terms
- Antifungal Agents, Candida albicans, Fungal Proteins, Humans, Saccharomyces cerevisiae, ATP-Binding Cassette Transporters, Drug Resistance, Multiple, Fungal, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins
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