Cited by 221Drug Transport and Resistance MechanismsFungal and yeast genetics researchAntifungal resistance and susceptibility

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Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

Prasad, Rajendra, Goffeau, Andre·2012·Annual Review of Microbiology

DOI 10.1146/annurev-micro-092611-150111

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Abstract

Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance. Yeasts are no exception. They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR) and in the cellular efflux of a wide variety of drugs. The PDR transporters Pdr5p of Saccharomyces cerevisiae and Cdr1p of Candida albicans are important members of this PDR subfamily, which comprises up to 10 phylogenetic clusters in fungi. Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters.

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Authors: Prasad, R., & Goffeau, A.
Affiliations: Jawaharlal Nehru University (IN)
Institut des Sciences de la Vie, Université Catholique de Louvain, Louvain-la-Neuve, 1349 Belgium;
ORCID: Prasad, Rajendra
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2012-10-13
Volume: 66
Issue: 1
Pages: 39-63
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev-micro-092611-150111
OpenAlex: W2101491044
Cited by: 221
References: 111
Citations by year: 2026: 4 · 2025: 10 · 2024: 17 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 12 · 2017: 17 · 2016: 25 · 2015: 21 · 2014: 18 · 2013: 20 · 2012: 4
FWCI: 2.08
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: ABC transporters, multidrug resistance, pleiotropic drug resistance, Pdr5p, Cdr1p, Saccharomyces cerevisiae, Candida albicans, drug efflux, ABC exporters
MeSH terms: Antifungal Agents, Candida albicans, Fungal Proteins, Humans, Saccharomyces cerevisiae, ATP-Binding Cassette Transporters, Drug Resistance, Multiple, Fungal, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins

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Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

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