Cited by 394Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Apolipoprotein E in Alzheimer's Disease: An Update

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Yu, Jin-Tai, Tan, Lan, Hardy, John·2014·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-071013-014300

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Abstract

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD. Although the mechanisms that underlie the pathogenic nature of APOE in AD are still not completely understood, emerging data suggest that APOE contributes to AD pathogenesis through both amyloid-β (Aβ)-dependent and Aβ-independent pathways. Given the central role for APOE in the modulation of AD pathogenesis, many therapeutic strategies have emerged, including converting APOE conformation, regulating APOE expression, mimicking APOE peptides, blocking the APOE/Aβ interaction, modulating APOE lipidation state, and gene therapy. Accumulating evidence also suggests the utility of APOE genotyping in AD diagnosis, risk assessment, prevention, and treatment response.

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Authors: Yu, J.-T., Tan, L., & Hardy, J.
Affiliations: Qingdao University (CN)
UCL Queen Square Institute of Neurology (GB)
ORCID: Yu, Jin-Tai
Tan, Lan
Hardy, John
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2014-07-08
Volume: 37
Issue: 1
Pages: 79-100
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-071013-014300
OpenAlex: W2097112082
Cited by: 394
References: 152
Citations by year: 2026: 7 · 2025: 15 · 2024: 27 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 39 · 2019: 46 · 2018: 47 · 2017: 46 · 2016: 46 · 2015: 27 · 2014: 14
FWCI: 5.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Natural Science Foundation of China (81000544, 81171209)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: apolipoprotein E, Alzheimer's disease, late-onset Alzheimer's disease, genetic risk factors, amyloid-beta, gene therapy, APOE genotyping, treatment options
MeSH terms: Alzheimer Disease, Apolipoproteins E, Brain, Genotype, Humans, Models, Biological, Signal Transduction, Amyloid beta-Peptides, tau Proteins, Genetic Predisposition to Disease, Molecular Targeted Therapy

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Apolipoprotein E in Alzheimer's Disease: An Update

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