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Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Abstract
Hypoxia develops in white adipose tissue in obese mice, resulting in changes in adipocyte function that may underpin the dysregulation that leads to obesity-associated disorders. Whether hypoxia occurs in adipose tissue in human obesity is unclear, with recent studies contradicting earlier reports that this was the case. Adipocytes, both murine and human, exhibit extensive functional changes in culture in response to hypoxia, which alters the expression of up to 1,300 genes. These include genes encoding key adipokines such as leptin, interleukin (IL)-6, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2), which are upregulated, and adiponectin, which is downregulated. Hypoxia also inhibits the expression of genes linked to oxidative metabolism while stimulating the expression of genes associated with glycolysis. Glucose uptake and lactate release by adipocytes are both stimulated by hypoxia, and insulin sensitivity falls. Preadipocytes and macrophages in adipose tissue also respond to hypoxia. The hypoxia-signaling pathway may provide a new target for the treatment of obesity-associated disorders.
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“Adipocytes release proinflammatory factors such as IL-6 and macrophage migration inhibitory factor (12).”
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Metadata
- Authors
- Trayhurn, P.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Trayhurn, Paul
- ORCID
- Trayhurn, Paul
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2014-07-17
- Volume
- 34
- Issue
- 1
- Pages
- 207-236
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2112850039
- Cited by
- 194
- References
- 207
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 18 · 2021: 22 · 2020: 13 · 2019: 19 · 2018: 20 · 2017: 24 · 2016: 18 · 2015: 17 · 2014: 6
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hypoxia, adipocytes, white adipose tissue, obesity, adipose tissue dysfunction, adipokines, leptin, adiponectin, interleukin-6, vascular endothelial growth factor, MMP-2, oxidative metabolism, glycolysis, glucose uptake, lactate release, insulin sensitivity, preadipocytes, macrophages, hypoxia signaling
- MeSH terms
- Animals, Energy Metabolism, Humans, Insulin Resistance, Macrophages, Models, Biological, Obesity, Cell Hypoxia, Adipogenesis, Hypoxia-Inducible Factor 1, Adipocytes, Brown, Adipocytes, White
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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