Cited by 194Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, Paul·2014·Annual Review of Nutrition

DOI 10.1146/annurev-nutr-071812-161156

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Abstract

Hypoxia develops in white adipose tissue in obese mice, resulting in changes in adipocyte function that may underpin the dysregulation that leads to obesity-associated disorders. Whether hypoxia occurs in adipose tissue in human obesity is unclear, with recent studies contradicting earlier reports that this was the case. Adipocytes, both murine and human, exhibit extensive functional changes in culture in response to hypoxia, which alters the expression of up to 1,300 genes. These include genes encoding key adipokines such as leptin, interleukin (IL)-6, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2), which are upregulated, and adiponectin, which is downregulated. Hypoxia also inhibits the expression of genes linked to oxidative metabolism while stimulating the expression of genes associated with glycolysis. Glucose uptake and lactate release by adipocytes are both stimulated by hypoxia, and insulin sensitivity falls. Preadipocytes and macrophages in adipose tissue also respond to hypoxia. The hypoxia-signaling pathway may provide a new target for the treatment of obesity-associated disorders.

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See all 194

Authors: Trayhurn, P.
Affiliations: University of Liverpool (GB)
Corresponding author: Trayhurn, Paul
ORCID: Trayhurn, Paul
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2014-07-17
Volume: 34
Issue: 1
Pages: 207-236
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev-nutr-071812-161156
OpenAlex: W2112850039
Cited by: 194
References: 207
Citations by year: 2026: 6 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 18 · 2021: 22 · 2020: 13 · 2019: 19 · 2018: 20 · 2017: 24 · 2016: 18 · 2015: 17 · 2014: 6
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: hypoxia, adipocytes, white adipose tissue, obesity, adipose tissue dysfunction, adipokines, leptin, adiponectin, interleukin-6, vascular endothelial growth factor, MMP-2, oxidative metabolism, glycolysis, glucose uptake, lactate release, insulin sensitivity, preadipocytes, macrophages, hypoxia signaling
MeSH terms: Animals, Energy Metabolism, Humans, Insulin Resistance, Macrophages, Models, Biological, Obesity, Cell Hypoxia, Adipogenesis, Hypoxia-Inducible Factor 1, Adipocytes, Brown, Adipocytes, White

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Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

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