The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Vitamin D as a Neurosteroid Affecting the Developing and Adult Brain
Open accessAbstract
Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research.
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“These findings suggest that depending on the timing of the exposure to low vitamin D status, different brain areas might be affected and the consequence might be different neurodevelopment and cognitive outcomes in infants [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
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“Mounting evidence suggests that low vitamin D status is involved in the aetiology of the mentioned abnormalities [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
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“Neurotrophins are involved in the development, maintenance, survival and synapsis of neurons [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
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Cited by
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Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110
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Biological pathways associated with vitamins in autism spectrum disorder
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Metadata
- Authors
- Groves, N. J., McGrath, J. J., & Burne, T. H. J.
- Affiliations
- The University of Queensland (AU)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2014-07-17
- Volume
- 34
- Issue
- 1
- Pages
- 117-141
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2101714022
- Cited by
- 256
- References
- 211
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 15 · 2023: 28 · 2022: 28 · 2021: 20 · 2020: 26 · 2019: 22 · 2018: 21 · 2017: 23 · 2016: 12 · 2015: 13 · 2014: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1070081)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- vitamin D, neurosteroids, vitamin D deficiency, brain development, neuroprotection, calcium signaling, neurotrophic factors, synaptic plasticity, neurotransmission, neuropsychiatric disorders, neurodegenerative diseases, vitamin D supplementation
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Models, Biological, Neurons, Vitamin D, Vitamin D Deficiency, Neurotransmitter Agents, Neuroprotective Agents, Dietary Supplements, Neurodegenerative Diseases, Neurogenesis
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