Genetic contributions to the etiology of anorexia nervosa: new perspectives in molecular diagnosis and treatment
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BACKGROUND: Anorexia nervosa is a multifactorial eating disorder that manifests with self-starvation, extreme anxiety, hyperactivity, and amenorrhea. Long-term effects include organ failure, disability, and in extreme cases, even death. METHODS: Through a literature search, here we summarize what is known about the molecular etiology of anorexia nervosa and propose genetic testing for this condition. RESULTS: Anorexia nervosa often has a familial background and shows strong heritability. Various genetic studies along with genome-wide association studies have identified several genetic loci involved in molecular pathways that might lead to anorexia. CONCLUSION: Anorexia nervosa is an eating disorder with a strong genetic component that contributes to its etiology. Various genetic approaches might help in the molecular diagnosis of this disease and in devising novel therapeutic options.
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Anorexia nervosa affects 0.9-4% of women and roughly 0.3% of men.
“Anorexia nervosa affects 0.9–4% of women and roughly 0.3% of men (39).”
From Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness (2022) · cites this paper as [39]
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Mendoza, A. D. G., Ruíz-Ramos, D., López‐Narváez, M. L., Tovilla‐Zárate, C. A., García, A. R. S., Meda, G. C., Martínez‐Magaña, J. J., González‐Castro, T. B., Juárez‐Rojop, I. E., & Nicolini, H. (2019) · Brain and Behavior · doi:10.1002/brb3.1286 · Cited by 15 · see citing works
Microduplications at the 15q11.2 BP1–BP2 locus are enriched in patients with anorexia nervosa
Chang, X., Qu, H., Liu, Y.-C., Glessner, J., Hou, C., Wang, F.-X., Li, J., Sleiman, P., & Hakonarson, H. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.01.021 · Cited by 13 · see citing works
Cannabinoid-1 receptor agonists: a therapeutic option in severe, chronic anorexia nervosa?
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Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets
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Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service
Curtis, D., Adlington, K., & Bhui, K. S. (2019) · The British Journal of Psychiatry · doi:10.1192/bjp.2019.48 · Cited by 4 · see citing works
Serotonin 4 Receptors: A Cornerstone in Anorexia Nervosa?
Compan, V. (2017) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 4 · see citing works
Serotonin 4 Receptors: A Cornerstone in Anorexia Nervosa?
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Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness
Christiansen, D. M., McCarthy, M. M., & Seeman, M. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856436 · Cited by 65 · see citing works
- Authors
- Paolacci, S., Kiani, A. K., Manara, E., Beccari, T., Ceccarini, M. R., Stuppia, L., Chiurazzi, P., Dalla Ragione, L., & Bertelli, M.
- Affiliations
- MAGI'S LAB Rovereto Trento Italy
- MAGI EUREGIO Bolzano Italy
- University of Perugia (IT)
- University of Chieti-Pescara (IT)
- Università Cattolica del Sacro Cuore (IT)
- Center for the Treatment of Eating Disorders Residenza Palazzo Francisci Todi Perugia Italy
- Corresponding author
- Paolacci, Stefano
- ORCID
- Venue
- Molecular Genetics & Genomic Medicine
- Publisher
- Wiley
- Published
- 2020-05-05
- Volume
- 8
- Issue
- 7
- Pages
- e1244-e1244
- ISSN
- 2324-9269 (ISSN-L)
- PMC
- PMC7336737
- OpenAlex
- W3021972487
- Cited by
- 47
- References
- 99
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 6
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Genetics & Genomic Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Provincia Autonoma di Bolzano (LP14/06 (dpg 25644/2019))
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- anorexia nervosa, genetic etiology, heritability, genome-wide association study, genetic loci, familial aggregation, molecular diagnosis, genetic testing, eating disorders, therapeutic target
- MeSH terms
- Animals, Anorexia Nervosa, Genetic Testing, Humans, Genetic Predisposition to Disease, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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