The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
The Pathogenesis of Mixed-Lineage Leukemia
Open accessAbstract
Aggressive leukemias arise in both children and adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large histone methyltransferase that directly binds DNA and positively regulates gene transcription, including homeobox (HOX) genes. MLL is involved in chromosomal translocations, partial tandem duplications, and amplifications, all of which result in hematopoietic malignancies due to sustained HOX expression and stalled differentiation. MLL lesions are associated with both acute myeloid leukemia and acute lymphoid leukemia and are usually associated with a relatively poor prognosis despite improved treatment options such as allogeneic hematopoietic stem cell transplantation, which underscores the need for new treatment regimens. Recent advances have begun to reveal the molecular mechanisms that drive MLL-associated leukemias, which, in turn, have provided opportunities for therapeutic development. Here, we discuss the etiology of MLL leukemias and potential directions for future therapy.
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Shelton, J., Lu, X., Hollenbaugh, J. A., Cho, J. H., Amblard, F., & Schinazi, R. F. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00209 · Cited by 409
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Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
Hughes, A. L., Kelley, J. R., & Klose, R. J. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194567 · Cited by 139
Metadata
- Authors
- Muntean, A. G., & Hess, J. L.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2012-02-28
- Volume
- 7
- Issue
- 1
- Pages
- 283-301
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2105740818
- Cited by
- 344
- References
- 105
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Muntean, A. G., & Hess, J. L. (2012). The Pathogenesis of Mixed-Lineage Leukemia. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-011811-132434
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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