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Cited by 139Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

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Hughes, Amy L., Kelley, Jessica R., Klose, Robert J.·2020·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
DOI 10.1016/j.bbagrm.2020.194567PMC PMC7294231
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Abstract

The precise regulation of gene transcription is required to establish and maintain cell type-specific gene expression programs during multicellular development. In addition to transcription factors, chromatin, and its chemical modification, play a central role in regulating gene expression. In vertebrates, DNA is pervasively methylated at CG dinucleotides, a modification that is repressive to transcription. However, approximately 70% of vertebrate gene promoters are associated with DNA elements called CpG islands (CGIs) that are refractory to DNA methylation. CGIs integrate the activity of a range of chromatin-regulating factors that can post-translationally modify histones and modulate gene expression. This is exemplified by the trimethylation of histone H3 at lysine 4 (H3K4me3), which is enriched at CGI-associated gene promoters and correlates with transcriptional activity. Through studying H3K4me3 at CGIs it has become clear that CGIs shape the distribution of H3K4me3 and, in turn, H3K4me3 influences the chromatin landscape at CGIs. Here we will discuss our understanding of the emerging relationship between CGIs, H3K4me3, and gene expression.

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Cited by

Sorted by citations

Authors
Hughes, A. L., Kelley, J. R., & Klose, R. J.
Affiliations
University of Oxford (GB)
Corresponding author
Klose, Robert J.
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher
Elsevier BV
Published
2020-08
Volume
1863
Issue
8
Pages
194567
ISSN
1874-9399 (ISSN-L)
DOI
10.1016/j.bbagrm.2020.194567
PMC
PMC7294231
OpenAlex
W3023686945
Cited by
139
References
11
Citations by year
2026: 13 · 2025: 26 · 2024: 30 · 2023: 25 · 2022: 24 · 2021: 18 · 2020: 3
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • European Research Council
  • Wellcome Trust
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
CpG islands, H3K4 trimethylation, histone methylation, promoter, DNA methylation, chromatin regulation, transcriptional regulation, cell type-specific gene expression, histone modifications
MeSH terms
Animals, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, Histones, Neoplasm Proteins, Promoter Regions, Genetic, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Transcription, Genetic, CpG Islands, DNA Methylation, Myeloid-Lymphoid Leukemia Protein

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