The DOI matches its Crossref record; 882 of the 882 references it cites were found in a registry or an index.
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Open accessAbstract
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, fibronectin, elastin, other glycoproteins and proteinases. In recent years, the field of PGs has expanded rapidly. Due to their high structural complexity and heterogeneity, PGs mediate several homeostatic and pathological processes. PGs consist of a protein core and one or more covalently attached GAG chains, which provide the protein cores with the ability to interact with several proteins. The GAG building blocks of PGs significantly influence the chemical and functional properties of PGs. The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis. Recent insights related to exosome biogenesis, degradation, and cell signaling, their status as diagnostic tools and potential pharmacological targets in diseases as well as current applications in nanotechnology and biotechnology are addressed. Moreover, issues related to docking studies, molecular modeling, GAG/PG interaction networks, and their integration are discussed.
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5 retracted
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Self-citationVersican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
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Structure of the human heparan sulfate polymerase complex EXT1-EXT2
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Metadata
- Authors
- Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., Ricard-Blum, S., Sanderson, R. D., Neill, T., & Iozzo, R. V.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-09-11
- Volume
- 118
- Issue
- 18
- Pages
- 9152-9232
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2890624098
- Cited by
- 367
- References
- 882
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., Ricard-Blum, S., Sanderson, R. D., Neill, T., & Iozzo, R. V. (2018). Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.8b00354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
