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Omics and Drug Response
Abstract
A new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advances is that the data generated document the uniqueness of each human being in regard to disease risk and treatment response. These developments have reemphasized the concept of personalized medicine. Here we review the impact of omics technologies on one key aspect of personalized medicine: the individual drug response. We describe how knowledge of different omics may affect treatment decisions, namely drug choice and drug dose, and how it can be used to improve clinical outcomes.
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From Case Report: Integrating clinical presentation and genetic analysis in P450 oxidoreductase deficiency: a novel mutation and systematic review (2026) · cites this paper as [65]
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Metadata
- Authors
- Meyer, U. A., Zanger, U. M., & Schwab, M.
- Affiliations
- University of Basel (CH)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Universitätsklinikum Tübingen (DE)
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2013-01-06
- Volume
- 53
- Issue
- 1
- Pages
- 475-502
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2098156682
- Cited by
- 157
- References
- 196
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 12 · 2019: 17 · 2018: 10 · 2017: 15 · 2016: 12 · 2015: 17 · 2014: 17 · 2013: 14
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Bosch Stiftung
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- National Human Genome Research Institute
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Keywords
- omics technologies, drug response, personalized medicine, pharmacogenomics, drug selection, drug dosing, treatment response variability, clinical outcomes, precision medicine
- MeSH terms
- Animals, Humans, Pharmacogenetics, Genomics, Precision Medicine
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