Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

The sequence of the human genome

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TGF-β SIGNAL TRANSDUCTION

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Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

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Network pharmacology: the next paradigm in drug discovery

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Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine

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The druggable genome

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High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

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Relating protein pharmacology by ligand chemistry

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Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Paoletta, S., Tosh, D. K., Salvemini, D., & Jacobson, K. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097858 · Cited by 25

Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold

Johansson, H., Boesgaard, M. W., Nørskov-Lauritsen, L., Larsen, I., Kuhne, S., Gloriam, D. E. I., Bräuner‐Osborne, H., & Pedersen, D. S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01254 · Cited by 25

Activation processes in ligand‐activated G protein‐coupled receptors: A case study of the adenosine A2A receptor

Prosser, R. S., Ye, L., Pandey, A. N., & Orazietti, A. P. (2017) · BioEssays · doi:10.1002/bies.201700072 · Cited by 26

Language as a Window Into the Altered State of Consciousness Elicited by Psychedelic Drugs

Tagliazucchi, E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.812227 · Cited by 25

Toward Selective Drug Development for the Human 5-Hydroxytryptamine 1E Receptor: A Comparison of 5-Hydroxytryptamine 1E and 1F Receptor Structure-Affinity Relationships

Klein, M. T., Dukat, M., Glennon, R. A., & Teitler, M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.179606 · Cited by 24

Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611

Kato, A., & Witkin, J. M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.09.015 · Cited by 22

Predicting GPCR Promiscuity Using Binding Site Features

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Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L., Belvisi, L., Bianchi, A., Conti, A., Drago, C., Matteo, M. D., Ferrante, L., Mastrangelo, E., Perego, P., Potenza, D., et al. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.09.020 · Cited by 20

Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling

Li, N., Yang, M.-Y., Zhang, M., Liu, N., Zhou, A.-W., Chai, Z., & Lu, S. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01603-w · Cited by 19

Screening and identification of CNIH4 gene associated with cell proliferation in gastric cancer based on a large-scale CRISPR-Cas9 screening database DepMap

Zhang, H., Lin, Y., Zhuang, M., Zhu, L., Dai, Y., & Lin, M. (2022) · Gene · doi:10.1016/j.gene.2022.146961 · Cited by 19

Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists

Matricon, P. G., Nguyen, A. T. N., Vo, D. D., Baltos, J., Jaiteh, M., Luttens, A., Kampen, S., Christopoulos, A., Kihlberg, J. O., May, L. T., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115419 · Cited by 19

Covalent conjugation of oligonucleotides with cell-targeting ligands

Alam, M. R., Ming, X., Nakagawa, O., Jin, J., & Juliano, R. L. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.05.037 · Cited by 19

Controlling absence seizures from the cerebellar nuclei via activation of the Gq signaling pathway

Schwitalla, J. C., Pakusch, J., Mücher, B., Brückner, A., Depke, D. A., Fenzl, T., Zeeuw, C. I. D., Kros, L., Hoebeek, F. E., & Mark, M. D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04221-5 · Cited by 18

Studies of a ubiquitous receptor family

Roth, B. L., & Marshall, F. H. (2012) · Nature · doi:10.1038/492057a · Cited by 18

Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics

Zheng, W., Zhou, J., Luan, Y., Yang, J., Ge, Y., Wang, M., Wu, B., Wu, Z., Chen, X., Li, F. Y., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00095 · Cited by 18

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain

Aldrin-Kirk, P., & Björklund, T. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9065-8_4 · Cited by 20

Activity Map and Transition Pathways of G Protein-Coupled Receptor Revealed by Machine Learning

Mollaei, P., & Farimani, A. B. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00032 · Cited by 17

Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications

Tian, W., & Chen, S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.616820 · Cited by 19

Probing the Existence of a Metastable Binding Site at the β 2 -Adrenergic Receptor with Homobivalent Bitopic Ligands

Gaiser, B. I., Danielsen, M., Märcher-Rørsted, E., Jørgensen, K. R., Wróbel, T. M., Frykman, M., Johansson, H., Bräuner‐Osborne, H., Gloriam, D. E. I., Mathiesen, J. M., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00595 · Cited by 18

G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders

Sun, Y., Hasbi, A., & George, S. R. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061724-080727 · Cited by 18

Split Luciferase Complementation for Analysis of Intracellular Signaling

Hattori, M., & Ozawa, T. (2014) · Analytical Sciences · doi:10.2116/analsci.30.539 · Cited by 16

Opportunities and challenges in drug discovery targeting the orphan receptor GPR12

Wang, P., Lv, L., Li, H., Wang, C., & Zhou, J. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103698 · Cited by 14

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ‐Opioid Receptor

Okude, J., Ueda, T., Kofuku, Y., Sato, M., Nobuyama, N., Kondo, K., Shiraishi, Y., Mizumura, T., Onishi, K., Natsume, M., et al. (2015) · Angewandte Chemie · doi:10.1002/ange.201508794 · Cited by 14

Binding sites in membrane proteins – Diversity, druggability and prospects

Adams, R. A., Worth, C. L., Günther, S., Dunkel, M., Lehmann, R., & Preißner, R. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.06.003 · Cited by 17

Interaction of Membrane Cholesterol with GPCRs: Implications in Receptor Oligomerization

Sengupta, D., Kumar, G. A., & Chattopadhyay, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-60174-8_16 · Cited by 14

A collage of cholesterol interaction motifs in the serotonin1A receptor: An evolutionary implication for differential cholesterol interaction.

Fatakia, S., Sarkar, P., & Chattopadhyay, A. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.02.010 · Cited by 13

Navigating High-Dimensional Activity Landscapes: Design and Application of the Ligand-Target Differentiation Map

Iyer, P., Dimova, D., Vogt, M., & Bajorath, J. (2012) · Journal of Chemical Information and Modeling · doi:10.1021/ci3002765 · Cited by 13

Addressing Selective Polypharmacology of Antipsychotic Drugs Targeting the Bioaminergic Receptors through Receptor Dynamic Conformational Ensembles

Selvam, B., Porter, S. L., & Tikhonova, I. G. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400282q · Cited by 13

A generic microfluidic biosensor of G protein-coupled receptor activation—monitoring cytoplasmic [Ca2+] changes in human HEK293 cells

Roelse, M., de Ruijter, N. C. A., Vrouwe, E. X., & Jongsma, M. A. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.03.065 · Cited by 13

The wonderful and masterful G protein-coupled receptor (GPCR): A focus on signaling mechanisms and the neuroendocrine control of fertility

Babwah, A. V. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110886 · Cited by 12

Spectral methods for study of the G-protein-coupled receptor rhodopsin: I. Vibrational and electronic spectroscopy

Владимирович, С. А., Barmasov, A. V., & Brown, M. F. (2015) · Optics and Spectroscopy · doi:10.1134/s0030400x15050240 · Cited by 12

Developing Photoaffinity Probes for Dopamine Receptor D 2 to Determine Targets of Parkinson’s Disease Drugs

Kim, S. T., Doukmak, E. J., Flax, R. G., Gray, D. J., Zirimu, V., de Jong, E. P., & Steinhardt, R. C. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00544 · Cited by 11

Structure–Activity Relationship Study of the High-Affinity Neuropeptide Y 4 Receptor Positive Allosteric Modulator VU0506013

Schüß, C., Vu, O., Mishra, N. M., Tough, I. R., Du, Y., Stichel, J., Cox, H. M., Weaver, C. D., Meiler, J., Emmitte, K. A., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00383 · Cited by 13

Bitopic Ligands Support the Presence of a Metastable Binding Site at the β2 Adrenergic Receptor

Gaiser, B. I., Danielsen, M., Xu, X., Jørgensen, K. R., Fronik, P., Märcher-Rørsted, E., Wróbel, T. M., Liu, X., Mathiesen, J. M., & Pedersen, D. S. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00578 · Cited by 11

Historeceptomic Fingerprints for Drug-Like Compounds

Shmelkov, E., Grigoryan, A., Swetnam, J., Xin, J., Tivon, D., Shmelkov, S. V., & Cardozo, T. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00371 · Cited by 11

Cell-Based Assays and Animal Models for GPCR Drug Screening

Takakura, H., Hattori, M., Tanaka, M., & Ozawa, T. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2336-6_18 · Cited by 11

Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study

Gao, N., Liang, T., Yuan, Y., Xiao, X., Zhao, Y., Guo, Y., Li, M., & Pu, X. (2016) · Physical Chemistry Chemical Physics · doi:10.1039/c6cp03710k · Cited by 11

GPCR profiling: from hits to leads and from genotype to phenotype

Cvijic, M. E., Sum, C. S., Alt, A. J., & Zhang, L. (2015) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2015.10.005 · Cited by 10

Viral Vector Delivery of DREADDs for CNS Therapy

Pickering, C. A., & Mazarakis, N. D. (2021) · Current Gene Therapy · doi:10.2174/1566523221666210211102435 · Cited by 11

Status of β1-Adrenoceptor Signal Transduction System in Cardiac Hypertrophy and Heart Failure

Dhalla, N. S., Bhullar, S. K., Adameová, A., Mota, K. O., & de Vasconcelos, C. M. L. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2409264 · Cited by 9

Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury

Steenbergen, V. V., & Bareyre, F. M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113839 · Cited by 8

A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells

Li, F., Jiang, X., Luo, L.-L., Xu, Y.-M., Huang, X., Huang, C., & Zhang, Y. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0359-x · Cited by 9

Designed dualsteric modulators: A novel route for drug discovery

Li, N., Zheng, G., Fu, L., Liu, N., Chen, T., & Lu, S. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104141 · Cited by 8

Whole-genome sequencing identified candidate genes associated with high and low litter size in Chuanzhong black goats

Guo, C., Ye, J., Liu, J., Li, Z., Deng, M., Guo, Y., Liu, G., Sun, B., Li, Y., & Liu, D. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1420164 · Cited by 8

From Nuclear Receptors to GPCRs: a Deep Transfer Learning Approach for Enhanced Environmental Estrogen Recognition

Yao, T., Luo, J., Han, X., Yi, H., Zhang, H., Pan, W., Xue, Q., Liu, X., Fu, J., & Zhang, A. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c02014 · Cited by 8

Functional Characterization of Sodium Channel Inhibitors at the Delta-Opioid Receptor

Mohamud, A. O., Zeghal, M., Patel, S., Laroche, G., Blgacim, N., & Giguère, P. M. (2022) · ACS Omega · doi:10.1021/acsomega.1c07226 · Cited by 8

Targeting the diuretic hormone receptor to control the cotton leafworm, Spodoptera littoralis

Apone, F., Ruggiero, A., Tortora, A., Tito, A., Grimaldi, M. R., Arciello, S., Andrenacci, D., Lelio, I. D., & Colucci, G. (2014) · Journal of Insect Science · doi:10.1093/jis/14.1.87 · Cited by 8

Senegalin: a novel antimicrobial/myotropic hexadecapeptide from the skin secretion of the African running frog, Kassina senegalensis

Wang, H., Li, R., Xi, X., Meng, T., Zhou, M., Wang, L., Zhang, Y., Chen, T., & Shaw, C. (2013) · Amino Acids · doi:10.1007/s00726-013-1470-8 · Cited by 8

Small expression tags enhance bacterial expression of the first three transmembrane segments of the apelin receptor

Pandey, A. N., Sarker, M., Liu, X., & Rainey, J. K. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0009 · Cited by 9

Impossible or Merely Difficult? Two Grand Challenges from a Biologist’s Perspective

Roth, B. L. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml4000386 · Cited by 8

Olfactory–gustatory cross-modal integration: mechanisms of aroma-induced sweetness enhancement, sensory evaluation methodologies, neuroimaging evidence and advances in influencing factors

Tan, Y., & Pang, X. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.043 · Cited by 8

GPCR Allostery: A View from Computational Biology

Li, M., Bao, Y., Li, M., & Guo, J. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230113125246 · Cited by 7

A novel splice variant of Gαq-coupled Bombyx CAPA-PVK receptor 1 functions as a specific Gαi/o-linked receptor for CAPA-PK

Cao, Z., Yan, L., Shen, Z., Chen, Y., Shi, Y., He, X., & Zhou, N. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118718 · Cited by 7

Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro

Orr‐Burks, N., Murray, J., Todd, K. V., Bakre, A. A., & Tripp, R. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259129 · Cited by 7

Drug–Target Interaction Prediction Based on an Interactive Inference Network

Chen, Y., Liang, X., Du, W., Liang, Y., Wong, G., & Chen, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147753 · Cited by 6

Therapeutic Potential of Functional Selectivity in the Treatment of Heart Failure

Christensen, G. L., Aplin, M., & Hansen, J. L. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2011.11.005 · Cited by 6

Predictive Modeling of Tox21 Data

Huang, R. (2019) · Challenges and advances in computational chemistry and physics · doi:10.1007/978-3-030-16443-0_14 · Cited by 6

Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction

Xu, X., Qiu, L., Zhang, M., & Wu, G. (2024) · Journal of Cell Science · doi:10.1242/jcs.261685 · Cited by 7

Structural diversity in ligand recognition by GPCRs

Jakowiecki, J., Miszta, P., Niewieczerzał, S., & Filipek, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00003-9 · Cited by 6

3D-QSAR and Molecular Docking Studies of Novel GPR52 Agonists

Gu, Q., Hou, J., Gao, H., Shi, M., Zhuang, Y., Wu, Q., & Zheng, L. (2023) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416523500308 · Cited by 6

An Atomic Level Investigation of Sodium Ions Regulating Agonist and Antagonist Binding in the Active Site of a Novel Target 5HT2BR Against Drug-Resistant Epilepsy

Chauhan, A., Singh, J., Sangwan, N., Dhawan, R., & Avti, P. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01143-2 · Cited by 6

Multiplexed Lipid Bilayers on Silica Microspheres for Analytical Screening Applications

Oropeza, N. F., Zurek, N. A., Cruz, M. G. L., Fabry‐Wood, A., Fetzer, J. M., Graves, S. W., & Shreve, A. P. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00296 · Cited by 7

A generic microfluidic biosensor of G protein-coupled receptor activation – impedance measurements of reversible morphological changes of reverse transfected HEK293 cells on microelectrodes

Srivastava, S. K., Ramaneti, R., Roelse, M., Tong, H. D., Vrouwe, E. X., Brinkman, A. G. M., de Smet, L. C. P. M., van Rijn, C. J. M., & Jongsma, M. A. (2015) · RSC Advances · doi:10.1039/c5ra04976h · Cited by 6

Modeling of Compound Profiling Experiments Using Support Vector Machines

Balfer, J., Heikamp, K., Laufer, S., & Bajorath, J. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12294 · Cited by 7

Molecular Dynamics and Machine Learning Study of Adrenaline Dynamics in the Binding Pocket of GPCR

Seshadri, K., & Krishnan, M. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.3c00401 · Cited by 5

Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

Hall, B., Squires, C., & Parker, K. (2012) · International Journal of Peptides · doi:10.1155/2012/490734 · Cited by 5

Strategies for Studying the Ligand Binding Site of GPCRs

Couvineau, A., Tan, Y., Ceraudo, E., & Laburthe, M. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391861-1.00010-1 · Cited by 5

Gut metabolites: make orphans adopted

Zhang, W., & Zhu, S. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz012 · Cited by 5

A novel label-free live-cell biosensor for G-protein-coupled receptor functional assay with enhanced sensitivity

Jin, P., Ren, Z., Ye, F., & Ying, W. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2013.12.036 · Cited by 5

Opsin expression varies across larval development and taxa in pteriomorphian bivalves

Hasan, M. S., McElroy, K. E., Audino, J. A., & Serb, J. M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1357873 · Cited by 4

Targeting the Diuretic Hormone Receptor to Control the Cotton Leafworm,Spodoptera littoralis

Apone, F., Ruggiero, A., Tortora, A., Tito, A., Grimaldi, M. R., Arciello, S., Andrenacci, D., Lelio, I. D., & Colucci, G. (2014) · Journal of Insect Science · doi:10.1673/031.014.87 · Cited by 4

Application of Biomolecular Simulations to G Protein–Coupled Receptors ( GPCRs )

Torrens‐Fontanals, M., Stępniewski, T. M., Rodríguez‐Espigares, I., & Selent, J. (2018) · Methods and principles in medicinal chemistry · doi:10.1002/9783527806836.ch8 · Cited by 4

Steric control of signaling bias in the immunometabolic receptor GPR84

Wang, P., Zhang, X., Guseinov, A. A., Jenkins, L., von Hallerstein, C., Colburn, J. D., Ives, R., Luscombe, V. B., Marsango, S., Oktavia, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77312-7 · Cited by 3

Dopamine receptor divergence revealed using a common ligand

Sibley, D. R., Nilson, A. N., Moritz, A. E., & Shi, L. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.08.002 · Cited by 3

GPR97 deficiency suppresses Wnt/β‐catenin signaling in hypertensive nephropathy

Gao, P., Zhu, J., Xiangyun, G., Li, J., & Wu, J. (2024) · The FASEB Journal · doi:10.1096/fj.202302298r · Cited by 3

The Inferential Binding Sites of GCGR for Small Molecules Using Protein Dynamic Conformations and Crystal Structures

Wang, M., Fu, X., Du, L., Shi, F., Huang, Z., & Yang, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158389 · Cited by 3

Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice

Lipina, T. V., Giang, H., Thacker, J. S., Wetsel, W. C., Caron, M. G., Beaulieu, J., Salahpour, A., & Ramsey, A. J. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae060 · Cited by 3

Quantifying GPCR Internalization: A Focus on the Kisspeptin Receptor

Pampillo, M., & Babwah, A. V. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2336-6_9 · Cited by 3

Polypharmacology and Adverse Bioactivity Profiles Predict Potential Toxicity and Drug‐Related Adrs

Kaserer, T., Temml, V., & Schuster, D. (2014) · doi:10.1002/9781118783344.ch2 · Cited by 3

Computational Strategies to Incorporate GPCR Complexity in Drug Design

Martí-Solano, M., Kaczor, A. A., Guixà-González, R., & Selent, J. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.1016/b978-1-60805-865-5.50001-0 · Cited by 2

Compound Structure‐Independent Activity Prediction in High‐Dimensional Target Space

Balfer, J., Hu, Y., & Bajorath, J. (2014) · Molecular Informatics · doi:10.1002/minf.201400051 · Cited by 2

Live Cell Bioluminescence Imaging in Temporal Reaction of G Protein-Coupled Receptor for High-Throughput Screening and Analysis

Hattori, M., & Ozawa, T. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3813-1_16 · Cited by 2

Impact of Replacing Fentanyl With Hydromorphone as the First-Line Postoperative Opioid Among Patients Undergoing Outpatient Cancer Surgery

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Computational design of allosteric pathways reprograms ligand-selective GPCR signalingPreprint

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