The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Endocrine-Disrupting Chemicals and Child Health
Abstract
While definitions vary, endocrine-disrupting chemicals (EDCs) have two fundamental features: their disruption of hormone function and their contribution to disease and disability. The unique vulnerability of children to low-level EDC exposures has eroded the notion that only the dose makes the thing a poison, requiring a paradigm shift in scientific and policy practice. In this review, we discuss the unique vulnerability of children as early as fetal life and provide an overview of epidemiological studies on programming effects of EDCs on neuronal, metabolic, and immune pathways as well as on endocrine, reproductive, and renal systems. Building on this accumulating evidence, we dispel and address existing myths about the health effects of EDCs with examples from child health research. Finally, we provide a list of effective actions to reduce exposure and subsequent harm that are applicable to individuals, communities, and policy-makers.
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“The consequences of endocrine disruption can be particularly dire when exposure takes place prenatally, as fetal development is a time particularly sensitive to chemical perturbations (Ghassabian et al., 2022).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Ghassabian et al., 2022
In the citing paper
“Prenatal life represents a susceptible window of development during which chemical exposures can permanently alter fetal development, leading to an increased likelihood of disease later in life.”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Ghassabian et al., 2022
Citations
Cites
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Long, C., Wang, S., Hong, Y., He, L., Li, X., Yan, F., & Zhou, Y. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116107
Environmental Exposures Increasing Risk for Cardiometabolic Disorders
Trasande, L. (2026) · Contemporary cardiology · doi:10.1007/978-3-032-14256-6_3
Self-citationEnvironmental and Occupational Exposures, Organ Toxicity and Biomarkers
Huo, R. (2026) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2026.145033
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Self-citationTrasande, L., Nelson, M. E., Alshawabkeh, A. N., Barrett, E. S., Buckley, J. P., Dabelea, D., Dunlop, A. L., Herbstman, J. B., Meeker, J. D., Naidu, M., et al. (2026) · Environment International · doi:10.1016/j.envint.2026.110548
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Gangaiah, A. K., Patil, M. M., Illalu, S., Parashiva, S., Gururaja, S., & Ratageri, V. (2026) · Karnataka Paediatric Journal · doi:10.25259/kpj_59_2026
Métodos de medición de disruptores endócrinos en niños
Acurio, C. J. M., Mantilla, C., Serrano, G. A. Q., & Paredes, L. Á. S. (2026) · Revista Científica Multidisciplinar G-nerando · doi:10.66473/rcmg.v7i2.1523
Metadata
- Authors
- Ghassabian, A., Vandenberg, L., Kannan, K., & Trasande, L.
- Affiliations
- New York University (US)
- University of Massachusetts Amherst (US)
- Corresponding author
- Trasande, Leonardo
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2022-01-06
- Volume
- 62
- Issue
- 1
- Pages
- 573-594
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W3200808253
- Cited by
- 112
- References
- 146
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 27 · 2023: 19 · 2022: 15
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (ES000260, UH3OD023305)
- National Institute of Environmental Health Sciences (ES-000260, U2CES026542, P30ES000260, R01ES022972, R01ES029779)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- endocrine disruptors, child health, developmental programming, low-dose exposure, prenatal exposure, brain development, metabolic pathways, immune pathways, reproductive health, kidney health, exposure reduction, environmental policy
- MeSH terms
- Child Health, Child, Humans, Endocrine Disruptors
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