The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Heart Valve Structure and Function in Development and Disease
Open accessAbstract
The mature heart valves are made up of highly organized extracellular matrix (ECM) and valve interstitial cells (VICs) surrounded by an endothelial cell layer. The ECM of the valves is stratified into elastin-, proteoglycan-, and collagen-rich layers that confer distinct biomechanical properties to the leaflets and supporting structures. Signaling pathways have critical functions in primary valvulogenesis as well as the maintenance of valve structure and function over time. Animal models provide powerful tools to study valve development and disease processes. Valve disease is a significant public health problem, and increasing evidence implicates aberrant developmental mechanisms underlying pathogenesis. Further studies are necessary to determine regulatory pathway interactions underlying valve pathogenesis in order to generate new avenues for novel therapeutics.
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Cited by
Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease
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Metadata
- Authors
- Hinton, R. B., & Yutzey, K. E.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2011-03-17
- Volume
- 73
- Issue
- 1
- Pages
- 29-46
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2099327671
- Cited by
- 498
- References
- 108
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
