The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Mitral valve disease—morphology and mechanisms
Open accessAbstract
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but—even in adult life—remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications. Mitral valve enlargement can determine left ventricular outflow tract obstruction in hypertrophic cardiomyopathy, and might be stimulated by potentially modifiable biological valvular–ventricular interactions. Mitral valve plasticity also allows adaptive growth in response to ventricular remodelling. However, adverse cellular and mechanobiological processes create relative leaflet deficiency in the ischaemic setting, leading to mitral regurgitation with increased heart failure and mortality. Our approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease.
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Burden of valvular heart diseases: a population-based study
Nkomo, V. T., Gardin, J. M., Skelton, T. N., Gottdiener, J. S., Scott, C. G., & Enriquez-Sarano, M. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69208-8 · Cited by 4,881
Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene
Dietz, H. C., Cutting, C. R., Pyeritz, R. E., Maslen, C. L., Sakai, L. Y., Corson, G. M., Puffenberger, E. G., Hamosh, A., Nanthakumar, E. J., Curristin, S. M., et al. (1991) · Nature · doi:10.1038/352337a0 · Cited by 2,070
Self-citationLoeys, B. L., Chen, J., Neptune, E. R., Judge, D. P., Podowski, M., Holm, T., Meyers, J., Leitch, C. C., Katsanis, N., Sharifi, N., et al. (2005) · Nature Genetics · doi:10.1038/ng1511 · Cited by 1,795
Self-citationLosartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Habashi, J. P., Judge, D. P., Holm, T. M., Cohn, R. D., Loeys, B. L., Cooper, T. K., Myers, L., Klein, E. C., Liu, G., Calvi, C., et al. (2006) · Science · doi:10.1126/science.1124287 · Cited by 1,794
Self-citationLancellotti, P., Tribouilloy, C., Hagendorff, A., Popescu, B. A., Edvardsen, T., Pierard, L. A., Badano, L., Zamorano, J. L., & On behalf of the Scientific Document Committee of the European Association of Cardiovascular Imaging: Thor Edvardsen, O. B. (2013) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jet105 · Cited by 1,734
Heritable Disorders of Connective Tissue
(1960) · Postgraduate Medical Journal · doi:10.1136/pgmj.36.415.346 · Cited by 1,527
Grigioni, F., Enriquez-Sarano, M., Zehr, K. J., Bailey, K. R., & Tajik, A. J. (2001) · Circulation · doi:10.1161/01.cir.103.13.1759 · Cited by 1,429
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Neptune, E. R., Frischmeyer, P. A., Arking, D. E., Myers, L., Bunton, T. E., Gayraud, B., Ramirez, F., Sakai, L. Y., & Dietz, H. C. (2003) · Nature Genetics · doi:10.1038/ng1116 · Cited by 1,404
Self-citationMaron, M. S., Olivotto, I., Betocchi, S., Casey, S. A., Lesser, J. R., Losi, M. A., Cecchi, F., & Maron, B. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021332 · Cited by 1,259
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed, L. A., Levy, D., Levine, R. A., Larson, M. G., Evans, J. C., Fuller, D. L., Lehman, B., & Benjamin, E. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907013410101 · Cited by 1,169
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Formate metabolism in health and disease
Pietzke, M., Meiser, J., & Vazquez, A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.05.012 · Cited by 218
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis
Goddard, L. M., Duchemin, A.-L., Ramalingan, H., Wu, B., Chen, M., Bamezai, S., Yang, J., Li, L., Morley, M. P., Wang, T., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.023 · Cited by 156
Future prospects in the tissue engineering of heart valves: a focus on the role of stem cells
Albert, B. J., & Butcher, J. T. (2023) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2023.2214313 · Cited by 8
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Metadata
- Authors
- Levine, R. A., Hagége, A. A., Judge, D. P., Padala, M., Dal-Bianco, J. P., Aikawa, E., Beaudoin, J., Bischoff, J., Bouatia-Naji, N., Bruneval, P., Butcher, J. T., Carpentier, A., Chaput, M., Chester, A. H., Clusel, C., Delling, F. N., Dietz, H. C., Dina, C., Durst, R., Fernandez-Friera, L., Handschumacher, M. D., Jensen, M. O., Jeunemaitre, X. P., Marec, H. L., Tourneau, T. L., Markwald, R. R., Mérot, J., Messas, E., Milan, D. P., Neri, T., Norris, R. A., Peal, D., Perrocheau, M., Probst, V., Pucéat, M., Rosenthal, N., Solis, J., Schott, J.-J., Schwammenthal, E., Slaugenhaupt, S. A., Song, J.-K., Yacoub, M. H., & for the Leducq Mitral Transatlantic Network
- Venue
- Nature Reviews Cardiology
- Published
- 2015-10-20
- Volume
- 12
- Issue
- 12
- Pages
- 689-710
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W1754892555
- Cited by
- 386
- References
- 206
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Levine, R. A., Hagége, A. A., Judge, D. P., Padala, M., Dal-Bianco, J. P., Aikawa, E., Beaudoin, J., Bischoff, J., Bouatia-Naji, N., Bruneval, P., Butcher, J. T., Carpentier, A., Chaput, M., Chester, A. H., Clusel, C., Delling, F. N., Dietz, H. C., Dina, C., Durst, R., . . . for the Leducq Mitral Transatlantic Network. (2015). Mitral valve disease—morphology and mechanisms. Nature Reviews Cardiology. https://doi.org/10.1038/nrcardio.2015.161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
