The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Chloride Channels: Often Enigmatic, Rarely Predictable
Open accessAbstract
Until recently, anion (Cl−) channels have received considerably less attention than cation channels. One reason for this may be that many Cl−channels perform functions that might be considered cell-biological, like fluid secretion and cell volume regulation, whereas cation channels have historically been associated with cellular excitability, which typically happens more rapidly. In this review, we discuss the recent explosion of interest in Cl−channels, with special emphasis on new and often surprising developments over the past five years. This is exemplified by the findings that more than half of the ClC family members are antiporters, and not channels, as was previously thought, and that bestrophins, previously prime candidates for Ca 2+-activated Cl−channels, have been supplanted by the newly discovered anoctamins and now hold a tenuous position in the Cl−channel world.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Graves, A. R., Curran, P. K., Smith, C. L., & Mindell, J. A. (2008) · Nature · doi:10.1038/nature06907 · Cited by 399
Stöhr, H., Heisig, J. B., Benz, P. M., Schöberl, S., Milenkovic, V. M., Strauss, O., Aartsen, W. M., Wijnholds, J., Weber, B. H. F., & Schulz, H. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5546-08.2009 · Cited by 216
Cited by
Cerebrospinal fluid secretion by the choroid plexus
Damkier, H. H., Brown, P. D., & Praetorius, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2013 · Cited by 606
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Li, S., Smith, K. D., Davis, J. H., Gordon, P. B., Breaker, R. R., & Strobel, S. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310439110 · Cited by 122
Anoctamin 2 identified as an autoimmune target in multiple sclerosis
Ayoglu, B., Mitsios, N., Kockum, I., Khademi, M., Zandian, A., Sjöberg, R., Forsström, B., Bredenberg, J., Lima Bomfim, I., Holmgren, E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518553113 · Cited by 111
Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels
(2023) · doi:10.3390/molecules28155753 · Cited by 5
Metadata
- Authors
- Duran, C., Thompson, C. H., Xiao, Q., & Hartzell, H. C.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2010-03-17
- Volume
- 72
- Issue
- 1
- Pages
- 95-121
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2134779286
- Cited by
- 338
- References
- 4
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chloride Channels: Often Enigmatic, Rarely Predictable. https://app.cochat.ai/papers/10.1146/annurev-physiol-021909-135811
- The paper
- Duran, C., Thompson, C. H., Xiao, Q., & Hartzell, H. C. (2010). Chloride Channels: Often Enigmatic, Rarely Predictable. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-021909-135811
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.