Role of Ion Channels and Transporters in Cell Migration
Abstract
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any cell in the body that is not motile at a given point in its life cycle. Important physiological processes intimately related to the ability of the respective cells to migrate include embryogenesis, immune defense, angiogenesis, and wound healing. On the other side, migration is associated with life-threatening pathologies such as tumor metastases and atherosclerosis. Research from the last ≈ 15 years revealed that ion channels and transporters are indispensable components of the cellular migration apparatus. After presenting general principles by which transport proteins affect cell migration, we will discuss systematically the role of channels and transporters involved in cell migration.
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A hyperpolarized Vm can increase intracellular Ca2+ via TRP channels, whereas membrane depolarization could activate voltage-gated Ca2+ channels.
“A hyperpolarized Vm can increase intracellular Ca2+ via TRP channels, whereas membrane depolarization could activate voltage-gated Ca2+ channels (Schwab et al., 2012).”
From Membrane potential and cancer progression (2013) · cites this paper as Schwab et al., 2012
Vm is regarded as an indirect factor that can affect cell migration, whose main regulatory role might be setting up the electrical driving force for Ca2+.
“Vm is regarded as an indirect factor that can affect cell migration, whose main regulatory role might be setting up the electrical driving force for Ca2+ (Prevarskaya et al., 2010; Schwab et al., 2012).”
From Membrane potential and cancer progression (2013) · cites this paper as Schwab et al., 2012
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- Authors
- Schwab, A., Fabian, A., Hanley, P. J., & Stock, C.
- Affiliations
- University of Münster (DE)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2012-10
- Volume
- 92
- Issue
- 4
- Pages
- 1865-1913
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2038765646
- Cited by
- 420
- References
- 15
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 23 · 2023: 28 · 2022: 26 · 2021: 43 · 2020: 44 · 2019: 40 · 2018: 28 · 2017: 33 · 2016: 32 · 2015: 30 · 2014: 37 · 2013: 19 · 2012: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- ion channels, membrane transporters, cell migration, cell motility, metastasis, atherosclerosis, angiogenesis, wound healing, immune defense, embryonic development, tissue homeostasis
- MeSH terms
- Animals, Cell Movement, Ion Channels, Ion Transport, Membrane Transport Proteins
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