Cited by 146Protein Structure and DynamicsPhotoreceptor and optogenetics researchIon channel regulation and function

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Electrical Modulation of Membrane Proteins: Enforced Conformational Oscillations and Biological Energy and Signal Transductions

Tsong, T Y·1990·Annual Review of Biophysics and Biophysical Chemistry

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Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific ...Read More

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Crossref · 10.1146/annurev.bb.19.060190.000503

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Electroporation of cell membranes
Tsong, T. Y. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82054-9 · Cited by 1,096
Self-citation
Emerging Technologies in Food Processing
Knorr, D., Fröhling, A., Jaeger, H., Reineke, K., Schlüter, O. K., & Schössler, K. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.102308.124129 · Cited by 419
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Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm bacteria
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“During this work, it has been noted that electric fields and currents can influence the organization of biological membranes (10, 28, 31, 35, 40, 42) and membrane analogs (1, 18), metabolic and developmental processes within both prokaryotic and eukaryotic cells (19, 24, 34, 38, 42), and possibly even the shape of the…”
Background
Activation of Na+ and K+ pumping modes of (Na, K)-ATPase by an oscillating electric field
Liu, D. S., Astumian, R. D., & Tsong, T. Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39108-2 · Cited by 199
Schwan equation and transmembrane potential induced by alternating electric field
Marszałek, P. E., Liu, D. S., & Tsong, T. Y. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82447-4 · Cited by 180
“The electrical parameters of a cell membrane would depend on the frequency of an ac field (13, 14, 27, 28).”
BackgroundSelf-citation
Comparative study on shelf life of orange juice processed by high intensity pulsed electric fields or heat treatment
Elez‐Martínez, P., Soliva‐Fortuny, R., & Martín‐Belloso, O. (2005) · European Food Research and Technology · doi:10.1007/s00217-005-0073-3 · Cited by 176
On electroporation of cell membranes and some related phenomena
Tsong, T. Y. (1990) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(90)80028-h · Cited by 158
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Inactivation of orange juice peroxidase by high‐intensity pulsed electric fields as influenced by process parameters
Elez‐Martínez, P., Aguiló‐Aguayo, I., & Martín‐Belloso, O. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2306 · Cited by 137
Food Processing by Pulsed Electric Fields: Treatment Delivery, Inactivation Level, and Regulatory Aspects
Góngora-Nieto, M. M., Sepulveda, D. R., Pedrow, P. D., et al. (2002) · LWT · doi:10.1006/fstl.2001.0880 · Cited by 129
Electric fields at the plasma membrane level: A neglected element in the mechanisms of cell signalling
Olivotto, M., Arcangeli, A., Carlà, M., & Wanke, E. (1996) · BioEssays · doi:10.1002/bies.950180612 · Cited by 127
High intensity pulsed electric field as an innovative technique for extraction of bioactive compounds—A review
Yan, L.-G., He, L., & Xi, J. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1077193 · Cited by 126
“Similarly, electroporation also occurs in the liposomes but the molecules affected by electric field are not necessarily the same (Tsong, 1990).”
Background
Cycle kinetics, steady state thermodynamics and motors—a paradigm for living matter physics
Qian, H. (2005) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/17/47/010 · Cited by 119
Pulsed Electric Fields
Barbosa‐Cánovas, G. V., Pierson, M. D., Zhang, Q. H., et al. (2000) · Journal of Food Science · doi:10.1111/j.1750-3841.2000.tb00619.x · Cited by 112
Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
Ross, C. L., Ang, D. C., & Almeida-Porada, G. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00266 · Cited by 105
An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields
Tuszynski, J., Wenger, C., Friesen, D., & Preto, J. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111128 · Cited by 95
Modulation of phospholipase A2 by electrostatic fields and dipole potential of glycosphingolipids in monolayers
Maggio, B. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32128-3 · Cited by 93
Applications of Innovative Non-Thermal Pulsed Electric Field Technology in Developing Safer and Healthier Fruit Juices
Roobab, U., Abida, A., Chacha, J. S., Athar, A., Madni, G. M., Ranjha, M. M. A. N., Rusu, A., Zeng, X.-A., Aadil, R. M., & Trif, M. (2022) · Molecules · doi:10.3390/molecules27134031 · Cited by 75
“The enzyme’s active sites are ultimately modified which makes it more problematic for the substrates to draw together, ultimately decreasing the values of the residual activity [88].”
Background
Color and viscosity of watermelon juice treated by high-intensity pulsed electric fields or heat
Aguiló‐Aguayo, I., Soliva‐Fortuny, R., & Martín‐Belloso, O. (2010) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2009.12.004 · Cited by 82
The use of electric, magnetic, and electromagnetic field for directed cell migration and adhesion in regenerative medicine
Ross, C. L. (2016) · Biotechnology Progress · doi:10.1002/btpr.2371 · Cited by 80
Pulsed Electric Fields Processing of Foods: An Overview
Barbosa‐Cánovas, G. V., & Altunakar, B. (2006) · Food engineering series · doi:10.1007/978-0-387-31122-7_1 · Cited by 78
Na,K‐ATPase function in alternating electric fields 1
Blank, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.7.1314204 · Cited by 75
“The electroconformational coupling model ( 23 ) accounts for the effect of an electric field on the enzyme through induced changes in conformation.”
Background
Functional architectures and structured flows on manifolds: A dynamical framework for motor behavior.
Huys, R., Perdikis, D., & Jirsa, V. (2014) · Psychological Review · doi:10.1037/a0037014 · Cited by 80
“Similarly, changes occurring at faster time scales, such as enzyme turnover in reaction processes (associated time constants of 10 6 to 10 3 s; Tsong, 1990; Tsong & Astumian, 1988), and other (fast) cell metabolism processes do not affect the phase flow (at least, in isolation).”
Background
Recognition and processing of randomly fluctuating electric signals by Na,K-ATPase
Xie, T. D., Marszałek, P. E., Chen, Y. D., & Tsong, T. Y. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80594-6 · Cited by 74
Self-citation
Molecular recognition and processing of periodic signals in cells: study of activation of membrane ATPases by alternating electric fields
Tsong, T. Y. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90034-8 · Cited by 69
Self-citation
Bioelectromagnetic medicine: The role of resonance signaling
Foletti, A., Grimaldi, S., Lisi, A., Ledda, M., & Liboff, A. R. (2013) · Electromagnetic Biology and Medicine · doi:10.3109/15368378.2012.743908 · Cited by 65
“…influenced by weak low-frequency MFs (Blackman, Benane, & House, 1993a,b; Blackman, Benane, House, & Elliot, 1990; Blackman, Kinney, House, & Joines, 1989; Blank & Soo, 1992, 1993a,b; Markin & Tsong, 1991a,b,c; Tsong, Liu, Chauvin, & Astumian, 1989; Tsong, 1990, 1992; Vincze et al., 2005).”
Reduction of Protease Activity in Milk by Continuous Flow High-Intensity Pulsed Electric Field Treatments
Bendicho, S., Barbosa‐Cánovas, G. V., & Martín‐Belloso, O. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73649-2 · Cited by 64
“Changes in enzyme structure might be caused by changes in the conformational state of proteins due to the application of electric fields, since charged groups and structures are highly susceptible to various types of electric field perturbations, and these changes cause a loss of its structure and consequently the los…”
Background
Quality-Related Enzymes in Plant-Based Products: Effects of Novel Food Processing Technologies Part 2: Pulsed Electric Field Processing
Terefe, N. S., Buckow, R., & Versteeg, C. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.701253 · Cited by 63
“The available scientific literature suggests that both electrochemical effects and thermal effects associated with PEF individually or in synergy may cause changes in the structure and conformation of enzymes (Tsong, 1990; English et al., 2009; Zhao and Yang, 2010), which can lead to inactivation.”
Background
Application of High-Intensity Pulsed Electrical Fields in Food Processing
Rastogi, N. K. (2003) · Food Reviews International · doi:10.1081/fri-120023478 · Cited by 61
“Association and dissociation of ionizable groups, movement of charged side chains, changes in the packing and alignment of packing and alignment of helices (helical or sheet content), and the overall shape of the protein may all be influenced by external electric fields ( Tsong, 1990a ).”
Background
Fluctuation-driven directional flow in biochemical cycle: further study of electric activation of Na,K pumps
Xie, T. D., Chen, Y., Marszałek, P. E., & Tsong, T. Y. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78894-5 · Cited by 59
Self-citation
Cancer proliferation and therapy: the Warburg effect and quantum metabolism
Demetrius, L., Coy, J. F., & Tuszyński, J. A. (2010) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-7-2 · Cited by 59
“Tsong and collaborators have demonstrated that dynamical processes govern the function of metabolic enzymes which can capture and transmit energy from oscillating electric fields [25] involving electro-conformational coupling [26] and electric modulation of membrane proteins [27].”
Michaelis-Menten equation for an enzyme in an oscillating electric field
Robertson, B., & Astumian, R. D. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82441-3 · Cited by 58
Reduction of Protease Activity in Simulated Milk Ultrafiltrate by Continuous Flow High Intensity Pulsed Electric Field Treatments
Bendicho, S., Barbosa‐Cánovas, G. V., & Martín‐Belloso, O. (2003) · Journal of Food Science · doi:10.1111/j.1365-2621.2003.tb08270.x · Cited by 54
Energy transduction between a concentration gradient and an alternating electric field
Markin, V. S., Tsong, T. Y., Astumian, R. D., & Robertson, B. (1990) · The Journal of Chemical Physics · doi:10.1063/1.458644 · Cited by 51
Self-citation
Current concepts of the interaction of weak electromagnetic fields with cells
Gläser, R. (1992) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(92)87001-b · Cited by 49
Study of mechanisms of electric field-induced DNA transfection. II. Transfection by low-amplitude, low-frequency alternating electric fields
Xie, T. D., & Tsong, T. Y. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82434-6 · Cited by 47
“However, as mentioned, electric fields that generate transmembrane potential in the range of millivolts are capable of activating membrane transport systems (30, 31, 34).”
BackgroundSelf-citation
Study of mechanisms of electric field-induced DNA transfection. IV. Effects of DNA topology on cell uptake and transfection efficiency
Xie, T. D., Sun, L., Zhao, H., et al. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81675-2 · Cited by 46
Self-citation
Quantum metabolism explains the allometric scaling of metabolic rates
Demetrius, L., & Tuszyński, J. A. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0310 · Cited by 44
“…collaborators have shown the existence of dynamical processes involving metabolic enzymes that can capture and transmit energy from oscillating electric fields (Westerhoff et al. 1986) involving electro-conformational coupling (Tsong 1987) and electric modulation of membrane proteins (Tsong 1990).”
Background
Biological Effects of Electric Shock and Heat Denaturation and Oxidation of Molecules, Membranes, and Cellular Functions
Tsong, T. Y., & Su, Z. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07958.x · Cited by 43
Self-citation
Inducer exclusion and the regulation of sugar transport
Saier, M. H., & Crasnier, M. (1996) · Research in Microbiology · doi:10.1016/s0923-2508(96)90150-3 · Cited by 42
The electrical properties of the nuclear envelope, and their possible role in the regulation of eukaryotic gene expression
Matzke, A. J. M., & Matzke, M. A. (1991) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(91)80002-k · Cited by 42
Frequency and concentration windows for the electric activation of a membrane active transport system
Markin, V. S., & Tsong, T. Y. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82345-1 · Cited by 40
“Recently, an electroconformational coupling model for biological free energy transduction (6) by means of the electrochemical potential gradient of an ion (7, 8) has been proposed (9-14).”
MethodSelf-citation
Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression
Davies, P. C. W., Demetrius, L., & Tuszyński, J. A. (2012) · AIP Advances · doi:10.1063/1.3697850 · Cited by 39
Resonance transduction of low level periodic signals by an enzyme: an oscillatory activation barrier model
Markin, V. S., Liu, D., Rosenberg, M. D., & Tsong, T. Y. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81913-6 · Cited by 38
Self-citation
Periodic forcing of a K+ channel at various temperatures
Petracchi, D., Pellegrini, M., Pellegrino, M., et al. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80978-6 · Cited by 37
Programming mammalian cell behaviors by physical cues
Huang, J., & Fussenegger, M. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.07.014 · Cited by 39
c-Fos Is Surface Active and Interacts Differentially with Phospholipid Monolayers
Borioli, G. A., Caputto, B. L., & Maggio, B. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4081 · Cited by 36
Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum
Noda, Y., Mori, A., Liburdy, R. P., et al. (2000) · Pathophysiology · doi:10.1016/s0928-4680(00)00039-0 · Cited by 35
Influence of nutrient supply and elicitors on glucosinolate production in E. sativa hairy root cultures
Kastell, A., Schreiner, M., Knorr, D., et al. (2017) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1355-8 · Cited by 32
Interpretation of the effect of an oscillating electric field on membrane enzymes
Robertson, B., & Astumian, R. D. (1992) · Biochemistry · doi:10.1021/bi00116a020 · Cited by 30
Enzymatic Inactivation by Pulsed Electric Fields
Martín‐Belloso, O., Marsellés-Fontanet, À. R., & Elez‐Martínez, P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411479-1.00009-7 · Cited by 29
Fluctuation-dissipation theorem imposes high-voltage fluctuations in biological ionic channels
Procópio, J., & Fornés, J. A. (1995) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.51.829 · Cited by 25
Changes in the Freshness and Bacterial Community of Fresh Pork in Controlled Freezing Point Storage Assisted by Different Electrostatic Field Usage Frequencies
Xu, Y., Wen, X., Zhang, D., Schroyen, M., Wang, D., Li, X., & Hou, C. (2023) · Food and Bioprocess Technology · doi:10.1007/s11947-023-03180-4 · Cited by 25
“If the size of the small hole on the cell membrane forms an irreversible large hole, the structure of the cell membrane can be destroyed, and the cell could eventually die (Ross, 2017; Tsong, 1990).”
On electroporation of cell membranes and some related phenomena
Tsong, T. Y. (1990) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(90)87529-s · Cited by 24
Self-citation
Time Sequence of Molecular Events in Electroporation
Tsong, T. Y. (1992) · Elsevier eBooks · doi:10.1016/b978-0-08-091727-6.50007-1 · Cited by 24
Self-citation
Effects of Emerging Processing Technologies on Food Material Properties
Jaeger, H., Reineke, K., Schössler, K., & Knorr, D. (2012) · doi:10.1002/9781118373903.ch9 · Cited by 24
Process performance analysis of pulsed electric field (PEF) food applications
Jäger, H. (2013) · DepositOnce · doi:10.14279/depositonce-3513 · Cited by 24
Electrical field manipulation of cancer cell behavior monitored by whole cell biosensing device
Hondroulis, E., Melnick, S. J., Zhang, X., et al. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9788-2 · Cited by 23
Vertical electric field induced bacterial growth inactivation on amorphous carbon electrodes
Jain, S., Sharma, A., & Basu, B. (2014) · Carbon · doi:10.1016/j.carbon.2014.09.048 · Cited by 22
“It has been shown that the external fields can affect the a-helix content and the orientation of membrane proteins in eukaryotic cells and the electrophoretic mobilities of bacterial membrane proteins [27,28].”
Background
Coupling of cell structure to cell metabolism and function
Pienta, K. J., & Hoover, C. N. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550104 · Cited by 22
Electroconformational coupling for ion transport in an oscillating electric field: Rectification versus active pumping
Markin, V. S., & Tsong, T. Y. (1991) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(91)80028-2 · Cited by 22
Self-citation
Ion channel enzyme in an oscillating electric field
Markin, V., Liu, D., Gimsa, J., Strobel, R. S., Rosenberg, M. D., & Tsong, T. Y. (1992) · The Journal of Membrane Biology · doi:10.1007/bf00231912 · Cited by 22
“To explain these phenomena, an electroconformational coupling (ECC) model has been proposed (Tsong & Astumian, 1986; Astumian et al., 1989; Astumian & Robertson, 1989; Markin et al., 1990, 1991; Robertson & Astumian, 1990a; Tsong, 1990; Weaver & Astumian, 1990).”
BackgroundMethodSelf-citation
Electrically Stimulated Membrane Breakdown
Tsong, T. Y. (1996) · Springer eBooks · doi:10.1007/978-1-4613-1159-1_2 · Cited by 22
Self-citation
Na,K-ATPase as A Brownian Motor: Electric Field-InducedConformational Fluctuation Leads to Uphill Pumping of Cation inthe Absence of ATP
Tsong, T. Y. (2002) · Journal of Biological Physics · doi:10.1023/a:1019991918315 · Cited by 21
Self-citation
Reversible mechanosensitive ion pumping as a part of mechanoelectrical transduction
Markin, V. S., & Tsong, T. Y. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82346-3 · Cited by 21
“PG In (A "IA')- ZAT 1PG PP In (K2JK14) ZAP (10) When the membrane is strained by external tension -y, the variation of the membrane area is partially determined by its elasticity and partially by conformational transitions of the transporter (29).”
BackgroundSelf-citation
Electroconformational coupling for ion transport in an oscillating electric field: rectification versus active pumping
Markin, V. S., & Tsong, T. Y. (1991) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(91)85600-t · Cited by 21
Self-citation
Effect of externally applied electrostatic fields on the surface topography of ceramide-enriched domains in mixed monolayers with sphingomyelin
Wilke, N., & Maggio, B. (2006) · Biophysical Chemistry · doi:10.1016/j.bpc.2006.02.008 · Cited by 19
Enzymatic Inactivation by Pulsed Electric Fields
Martín‐Belloso, O., & Elez‐Martínez, P. (2005) · Elsevier eBooks · doi:10.1016/b978-012676757-5/50009-8 · Cited by 18
Functional responses between PMP3 small membrane proteins and membrane potential
Kwok, A. C. M., Zhang, F., Ma, Z., Chan, W. S., Yu, V. C., Tsang, J. S. H., & Wong, J. T. Y. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15027 · Cited by 17
Investigating the potential of polyphenol oxidase as a temperature-time-indicator for pulsed electric field treatment
Moritz, J., Balasa, A., Jaeger, H., et al. (2011) · Food Control · doi:10.1016/j.foodcont.2011.11.016 · Cited by 16
Statistical analyses and computational prediction of helical kinks in membrane proteins
Huang, Y. H., & Chen, C. (2012) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-012-9607-5 · Cited by 16
“5 [11, 31].”
Low-Frequency Electromagnetic Pulsed Field Stimulation of Yeast
Bolognani, L., Monte, V. D., Francia, F., Venturelli, T., Volpi, N., & Costato, M. (1992) · Electro- and Magnetobiology · doi:10.3109/15368379209012847 · Cited by 16
Comparison of conventional heat treatment with selected non-thermal technologies for the inactivation of the commercial protease Protamex™
Arroyo, C., Kennedy, T. M., Lyng, J. G., et al. (2017) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2017.06.004 · Cited by 15
Weak AC-electric fields promote root growth and ER abundance of root cap cells
Stenz, H. G., Wohlwend, B., & Weisenseel, M. H. (1998) · Bioelectrochemistry and Bioenergetics · doi:10.1016/s0302-4598(97)00071-8 · Cited by 15
Entrainment of Na/K pumps by a synchronization modulation electric field
Chen, W., Zhang, Z., & Huang, F. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9096-8 · Cited by 15
“In an excellent review (Tsong 1990), Tsong elaborated the concept of electric field-induced conformational changes in the proteins.”
Background
Ion pump as Brownian motor: theory of electroconformational coupling and proof of ratchet mechanism for Na,K-ATPase action
Tsong, T. Y., & Chang, C.-H. (2003) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(02)01793-4 · Cited by 15
Self-citation
AC fields of low frequency and amplitude stimulate pollen tube growth possibly via stimulation of the plasma membrane proton pump
Plätzer, K., Obermeyer, G., & Bentrup, F. (1997) · Bioelectrochemistry and Bioenergetics · doi:10.1016/s0302-4598(96)05164-1 · Cited by 14
KPFM and PFM of Biological Systems
Rodriguez, B. J., & Kalinin, S. V. (2011) · Springer series in surface sciences · doi:10.1007/978-3-642-22566-6_12 · Cited by 12
A novel method for the observation of membrane transporter dynamics
Horn, L. W. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81365-1 · Cited by 13
Synchronization of Ion Exchangers by an Oscillating Electric Field: Theory
Chen, W. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp0754637 · Cited by 12
Externally Applied Electric Fields on Immiscible Lipid Monolayers: Repulsion between Condensed Domains Precludes Domain Migration
Wilke, N., Dassie, S. A., Leiva, E. P. M., & Maggio, B. (2006) · Langmuir · doi:10.1021/la0614076 · Cited by 12
Emerging Technologies for Targeted Food Processing
Knorr, D., Froehling, A., Jaeger, H., et al. (2013) · Food engineering series · doi:10.1007/978-1-4614-7906-2_17 · Cited by 12
PEF Inactivation of Vegetative Cells, Spores, and Enzymes in Foods
Barbosa‐Cánovas, G. V., Góngora-Nieto, M. M., Pothakamury, U. R., & Swanson, B. G. (1999) · Elsevier eBooks · doi:10.1016/b978-012078149-2/50006-4 · Cited by 12
What a feeling - the underpinnings of physical feelings as molecular level holonomic effects. Journal of Multiscale Neuroscience 1(1), 11-40
Integrative Neuroscience Group AUS, & Poznanski, R. R. (2022) · Journal of Multiscale Neuroscience · doi:10.56280/1531676942 · Cited by 11
Stochastic resonance in an ion channel following the non-Arrhenius gating rate
Parc, Y. W., Koh, D. S., & Sung, W. (2009) · The European Physical Journal B · doi:10.1140/epjb/e2009-00116-5 · Cited by 11
Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP)
Šilkūnienė, G., Mangalanathan, U. M., Rossi, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119191 · Cited by 10
Electroinsertion and activation of the C-terminal domain of Colicin A, a voltage gated bacterial toxin, into mammalian cell membranes
Raffy, S., Lazdunski, C. J., & Teissié, J. (2004) · Molecular Membrane Biology · doi:10.1080/09687680410001711632 · Cited by 10
“Application of a low electric field intensity was used to generate a transmembrane potential prone to induce the ionic channel opening (Graziana et al. 1990, Tsong 1990).”
Method
Therapeutic Applications of Low Frequency Electric and Magnetic Fields
Polk, C. (1994) · Advances in electromagnetic fields in living systems · doi:10.1007/978-1-4615-2542-4_4 · Cited by 10
Synchronization modulation of Na/K pump molecules can hyperpolarize the membrane resting potential in intact fibers
Chen, W., & Dando, R. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9068-4 · Cited by 10
“An excellent review paper by Tsong (Tsong, 1990) summarized the potential mechanisms involved in pump-activation.”
Background
Determination of pore edge tension from the kinetics of rupture of giant unilamellar vesicles using the Arrhenius equation: effects of sugar concentration, surface charge and cholesterol
Karal, M. A. S., Billah, M. M., & Ahamed, M. K. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp04451c · Cited by 9
Effects of sugar concentration on the electroporation, size distribution and average size of charged giant unilamellar vesicles
Sarkar, M. K., Karal, M. A. S., Levadny, V., et al. (2022) · European Biophysics Journal · doi:10.1007/s00249-022-01607-y · Cited by 9
“1988; Tsong 1990; Hibino et al.”
Effect of the number of molecules on the energetic efficiency in molecular motors using the Flashing Ratchet model
Mouri, K., & Shimokawa, T. (2008) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2008.05.017 · Cited by 9
Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics
Chen, C.-C., Wei, C.-C., Sun, Y.-C., et al. (2008) · Journal of Structural Biology · doi:10.1016/j.jsb.2008.01.003 · Cited by 9
Reversibility of Thermally Induced Denaturation of Cellular Proteins
Tsong, T. Y., & Gross, C. J. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb30435.x · Cited by 9
Self-citation
A MULTI-DISCIPLINARY SURVEY OF BIOCOMPUTING: 1. MOLECULAR AND CELLULAR LEVELS
Hong, F. T. (2005) · Series on advances in bioinformatics and computational biology · doi:10.1142/9781860946882_0001 · Cited by 8
Replica exchange Monte-Carlo simulations of helix bundle membrane proteins: rotational parameters of helices
Wu, H., Chen, C., Chen, C.-M., et al. (2012) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-012-9562-1 · Cited by 8
“5 (its value is between 2 and 4) [51].”
Background
Oscillations in Plants
Shabala, S. N. (2006) · Springer eBooks · doi:10.1007/978-3-540-28516-8_18 · Cited by 8
“Examples include photosynthetic responses (Kocks and Ross 1995), membrane transport activity (Markevich and Sel’kov 1986; Tsong 1990) and energy transduction in glycolysis (Termonia and Ross 1982).”
Background
Plasma‐membrane‐Bound mcromoleculas are dynamically aggregated to form non‐random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?
Vereb, G., Mátyus, L., Bene, L., et al. (1995) · Journal of Molecular Recognition · doi:10.1002/jmr.300080402 · Cited by 8
“Electro- conformational couplings (Tsong, 1990) may also cause changes in the cell surface pattern similar to those mentioned previously in connection with transverse molecular relocalization.”
Background
Distribution of AC Electric Field‐Induced Transmembrane Voltage in Escherichia coli Cell Wall Layers
Rauly, D., Vindret, M., Chambérod, E., et al. (2020) · Bioelectromagnetics · doi:10.1002/bem.22261 · Cited by 7
Charge transfer across a single lipid-water interface causes ion pumping across the bilayer
Sun, K., & Mauzerall, D. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79226-3 · Cited by 7

Authors: Tsong, T. Y.
Affiliations: University of Minnesota (US)
Corresponding author: Tsong, T Y
Venue: Annual Review of Biophysics and Biophysical Chemistry
Publisher: Annual Reviews
Published: 1990-06
Volume: 19
Issue: 1
Pages: 83-106
ISSN: 0883-9182 (ISSN-L)
DOI: 10.1146/annurev.bb.19.060190.000503
OpenAlex: W2176765622
Cited by: 146
References: 0
Citations by year: 2026: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 5
FWCI: 3.99
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biophysics and Biophysical Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: signal transduction, CRISPR/Cas9, RNA-guided DNA endonuclease, bacterial defense against phages, conjugative plasmids
MeSH terms: Sodium-Potassium-Exchanging ATPase, Adenosine Triphosphate, Biophysics, Electrochemistry, Energy Metabolism, Membrane Fusion, Membrane Proteins, Protein Conformation, Signal Transduction, Biophysical Phenomena

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Electrical Modulation of Membrane Proteins: Enforced Conformational Oscillations and Biological Energy and Signal Transductions

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