The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution
Abstract
β-lactamases are enzymes that protect bacteria from the lethal effects of β-lactam antibiotics, and are therefore of considerable clinical importance. The crystal structure of β-lactamase from the Gram-positive bacterium Staphylococcus aureus PC1 has been determined at 2.5 angstrom resolution. It reveals a molecule of novel topology, made up of two closely associated domains. The active site is located at the interface between the domains, with the key catalytic residue Ser 70 at the amino terminus of a buried helix. Examination of the disposition of the functionally important residues within the active site depression leads to a model for the binding of a substrate and a functional analogy to the serine proteases. The unusual topology of the secondary structure units is relevant to questions concerning the evolutionary relation to the β-lactam target enzymes of the bacterial cell wall.
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Cited by
Three Decades of β-Lactamase Inhibitors
Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709
A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019
Page, M. G. P. (2012) · Antibiotic Discovery and Development · doi:10.1007/978-1-4614-1400-1_3 · Cited by 84
Metadata
- Authors
- Herzberg, O., & Moult, J.
- Venue
- Science
- Published
- 1987-05-08
- Volume
- 236
- Issue
- 4802
- Pages
- 694-701
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026130809
- Cited by
- 351
- References
- 29
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Herzberg, O., & Moult, J. (1987). Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution. Science. https://doi.org/10.1126/science.3107125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
