The Expression of Isotope Effects on Enzyme-Catalyzed Reactions
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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If kinetic isotope effect is used to describe a cascade of reaction steps instead of an elementary chemical reaction, the value will be affected by all processes leading up to and including the first irreversible step.
“If kinetic isotope effect is used to describe a cascade of reaction steps instead of an elementary chemical reaction (e.g., in enzyme reactions or environmental processes), the value will be affected by all processes leading up to and including the first irreversible step.[22]”
From Guidelines and recommended terms for expression of stable-isotope-ratio and gas-ratio measurement results (2011) · cites this paper as [22]
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Coplen, T. B. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5129 · Cited by 1,831 · see citing works
“cases, it is recommended that the term ‘apparent kinetic isotope effect’ be used.([21,22])”
Background
- Authors
- Northrop, D. B.
- Corresponding author
- Northrop, D B
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1981-06
- Volume
- 50
- Issue
- 1
- Pages
- 103-131
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2130327573
- Cited by
- 279
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
- Keywords
- isotope effects, enzyme kinetics, enzymatic reactions, isotopic labeling, reaction mechanism
- MeSH terms
- Binding, Competitive, Carbon Radioisotopes, Deuterium, Enzymes, Isotope Labeling, Kinetics, Mathematics, Terminology as Topic, Oxygen Isotopes, Radioisotope Dilution Technique
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