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HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES
Abstract
Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related proteins. All seven isozymes have been cloned, sequenced, and mapped, and the intron-exon organization of five genes established. They differ in subcellular localizations, being cytoplasmic (CA I, II, III, and VII), GPI-anchored to plasma membranes of specialized epithelial and endothelial cells (CA IV), in mitochondria (CA V), or in salivary secretions (CA VI). They also differ in kinetic properties, susceptibility to inhibitors, and tissue-specific distribution. Structural and kinetic studies of recombinant natural and mutant CAs have greatly increased our understanding of the structural requirements for catalysis. Studies of the effects of CA inhibitors over many years have implicated CAs in a variety of physiological processes. Analyses of human and animal CA deficiencies provide unique opportunities to understand the individual contributions of different isozymes to these processes.
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Cites
X-ray analysis of metal-substituted human carbonic anhydrase II derivatives
Håkansson, K., Wehnert, A., & Liljas, A. (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444993008790 · Cited by 71
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Structure and mechanism of carbonic anhydrase
Lindskog, S. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00198-2 · Cited by 1,022
Prokaryotic carbonic anhydrases
Smith, K. (2000) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(00)00030-9 · Cited by 678
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer-Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Alvarez, B., & Radi, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 640
Dental Enamel Formation and Implications for Oral Health and Disease
Lacruz, R. S., Habelitz, S., Wright, J. T., & Paine, M. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00030.2016 · Cited by 599
Metadata
- Authors
- Sly, W. S., & Hu, P. Y.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1995-06
- Volume
- 64
- Issue
- 1
- Pages
- 375-401
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2146370713
- Cited by
- 830
- References
- 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sly, W. S., & Hu, P. Y. (1995). HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.bi.64.070195.002111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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