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Cited by 830

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES

Sly, William S., Hu, Peiyi Y.·1995·Annual Review of Biochemistry

Abstract

Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related proteins. All seven isozymes have been cloned, sequenced, and mapped, and the intron-exon organization of five genes established. They differ in subcellular localizations, being cytoplasmic (CA I, II, III, and VII), GPI-anchored to plasma membranes of specialized epithelial and endothelial cells (CA IV), in mitochondria (CA V), or in salivary secretions (CA VI). They also differ in kinetic properties, susceptibility to inhibitors, and tissue-specific distribution. Structural and kinetic studies of recombinant natural and mutant CAs have greatly increased our understanding of the structural requirements for catalysis. Studies of the effects of CA inhibitors over many years have implicated CAs in a variety of physiological processes. Analyses of human and animal CA deficiencies provide unique opportunities to understand the individual contributions of different isozymes to these processes.

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Metadata

Authors
Sly, W. S., & Hu, P. Y.
Venue
Annual Review of Biochemistry
Published
1995-06
Volume
64
Issue
1
Pages
375-401
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
OpenAlex
W2146370713
Cited by
830
References
1
FWCI
5.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES. https://app.cochat.ai/papers/10.1146/annurev.bi.64.070195.002111
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Sly, W. S., & Hu, P. Y. (1995). HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.bi.64.070195.002111

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