The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Abstract
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O 2 •– ) and nitric oxide ( • NO). In this review, we first analyze the biochemical evidence for the formation of peroxynitrite in vivo and the reactions that lead to it. Then, we describe the principal reactions that peroxynitrite undergoes with biological targets and provide kinetic and mechanistic details. In these reactions, peroxynitrite has roles as (1) peroxide, (2) Lewis base, and (3) free radical generator. Physiological levels of CO 2 can change the outcome of peroxynitrite reactions. The second part of the review assesses the formation of protein 3-nitrotyrosine (NO 2 Tyr) by peroxynitrite-dependent and -independent mechanisms, as one of the hallmarks of the actions of • NO-derived oxidants in biological systems. Moreover, tyrosine nitration impacts protein structure and function, tyrosine kinase signal transduction cascades and protein turnover. Overall, the review is aimed to provide an integrated biochemical view on the formation and reactions of peroxynitrite under biologically relevant conditions and the impact of this stealthy oxidant and one of its major footprints, protein NO 2 Tyr, in the disruption of cellular homeostasis.
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Self-citationOxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine
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Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Di Mascio, P., Martinez, G. R., Miyamoto, S., Ronsein, G. E., Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 659
Detection, identification, and quantification of oxidative protein modifications
Hawkins, C. L., & Davies, M. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.006217 · Cited by 426
Redox Signaling by Reactive Electrophiles and Oxidants
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Metadata
- Authors
- Ferrer-Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Alvarez, B., & Radi, R.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-05
- Volume
- 118
- Issue
- 3
- Pages
- 1338-1408
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2787052956
- Cited by
- 640
- References
- 52
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
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