Cited by 1,175Nuclear Structure and FunctionDrug Transport and Resistance MechanismsCellular transport and secretion

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NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

Mattaj, Iain W., Englmeier, Ludwig·1998·Annual Review of Biochemistry

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Abstract

Active transport between the nucleus and cytoplasm involves primarily three classes of macromolecules: substrates, adaptors, and receptors. Some transport substrates bind directly to an import or an export receptor while others require one or more adaptors to mediate formation of a receptor-substrate complex. Once assembled, these transport complexes are transferred in one direction across the nuclear envelope through aqueous channels that are part of the nuclear pore complexes (NPCs). Dissociation of the transport complex must then take place, and both adaptors and receptors must be recycled through the NPC to allow another round of transport to occur. Directionality of either import or export therefore depends on association between a substrate and its receptor on one side of the nuclear envelope and dissociation on the other. The Ran GTPase is critical in generating this asymmetry. Regulation of nucleocytoplasmic transport generally involves specific inhibition of the formation of a transport complex; however, more global forms of regulation also occur.

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Crossref · 10.1146/annurev.biochem.67.1.265

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Authors: Mattaj, I. W., & Englmeier, L.
Affiliations: European Molecular Biology Laboratory (DE)
ORCID: Mattaj, Iain W.
Englmeier, Ludwig
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1998-06
Volume: 67
Issue: 1
Pages: 265-306
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.67.1.265
OpenAlex: W2151298994
Cited by: 1,175
References: 303
Citations by year: 2026: 6 · 2025: 6 · 2024: 8 · 2023: 14 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 11 · 2014: 24 · 2013: 26 · 2012: 27
FWCI: 9.51
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: nuclear transport, nuclear import, nuclear export, nuclear pore complex, Ran GTPase, transport receptors, transport regulation, nuclear envelope
MeSH terms: Biological Transport, Active, Cell Nucleus, Cytoplasm, Nuclear Envelope, Solubility, Cell Polarity, Receptors, Cytoplasmic and Nuclear, Nuclear Localization Signals

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NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

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