STATs: transcriptional control and biological impact

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works

STATs in oncogenesis

Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743 · see citing works

Specific Inhibition of Stat3 Signal Transduction by PIAS3

Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., & Shuai, K. (1997) · Science · doi:10.1126/science.278.5344.1803 · Cited by 980 · see citing works

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Levy, D. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00027-7 · Cited by 428 · see citing works

Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway

You, M., Yu, D.-H., & Feng, G.-S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2416 · Cited by 364 · see citing works

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

Cao, X., Tay, A., Guy, G. R., & Tan, Y. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1595 · Cited by 359 · see citing works

Stat1 Depends on Transcriptional Synergy with Sp1

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A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

Haspel, R. L., & Darnell, J. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10188 · Cited by 203 · see citing works

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works

Interferon-stimulated genes: A complex web of host defenses

Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

Mechanisms and consequences of Jak–STAT signaling in the immune system

Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221 · see citing works

Transcription factors as targets for cancer therapy

Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194 · see citing works

Evasion of Type I Interferon by SARS-CoV-2

Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y.-C., Wang, H., Menachery, V. D., Rajsbaum, R., & Shi, P.-Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108234 · Cited by 957 · see citing works

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., & Zhou, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00641-0 · Cited by 773 · see citing works

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., & Levy, D. E. (2009) · Science · doi:10.1126/science.1171721 · Cited by 716 · see citing works

OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism

Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724 · see citing works

Constitutive activation of <scp>STAT</scp>3 in breast cancer cells: A review

Banerjee, K., & Resat, H. (2016) · International Journal of Cancer · doi:10.1002/ijc.29923 · Cited by 611 · see citing works

SOCS3, a Major Regulator of Infection and Inflammation

Carow, B., & Rottenberg, M. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00058 · Cited by 555 · see citing works

The role of STAT3 in autophagy

You, L., Wang, Z., Li, H., Shou, J., Jing, Z., Xie, J., Sui, X., Pan, H., & Han, W. (2015) · Autophagy · doi:10.1080/15548627.2015.1017192 · Cited by 515 · see citing works

Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation

Reid, S. P., Leung, L. W., Hartman, A. L., Martinez, O., Shaw, M. L., Carbonnelle, C., Volchkov, V. E., Nichol, S. T., & Basler, C. F. (2006) · Journal of Virology · doi:10.1128/jvi.02349-05 · Cited by 463 · see citing works

The potential and controversy of targeting STAT family members in cancer

Verhoeven, Y., Tilborghs, S., Jacobs, J., De Waele, J., Quatannens, D., Deben, C., Prenen, H., Pauwels, P., Trinh, X. B., Wouters, A., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.002 · Cited by 409 · see citing works

Roles of unphosphorylated STATs in signaling

Yang, J., & Stark, G. R. (2008) · Cell Research · doi:10.1038/cr.2008.41 · Cited by 347 · see citing works

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases

Ben Haim, L., Ceyzériat, K., Carrillo-de Sauvage, M. A., Aubry, F., Auregan, G., Guillermier, M., Ruiz, M., Petit, F., Houitte, D., Faivre, E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-14.2015 · Cited by 335 · see citing works

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

Qiao, Y., Giannopoulou, E. G., Chan, C. H., Park, S.-H., Gong, S., Chen, J., Hu, X., Elemento, O., & Ivashkiv, L. B. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.009 · Cited by 330 · see citing works

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

Wang, Y., van Boxel-Dezaire, A. H. H., Cheon, H., Yang, J., & Stark, G. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315862110 · Cited by 327 · see citing works

Validating Stat3 in cancer therapy

Darnell, J. E. (2005) · Nature Medicine · doi:10.1038/nm0605-595 · Cited by 307 · see citing works

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

Spangler, J. B., Moraga, I., Mendoza, J. L., & Garcia, K. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120211 · Cited by 304 · see citing works

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

Bancerek, J., Poss, Z. C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Müller, M., Taatjes, D. J., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.017 · Cited by 297 · see citing works

Genomic views of STAT function in CD4+ T helper cell differentiation

O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works

Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

Varinou, L., Ramsauer, K., Karaghiosoff, M., Kolbe, T., Pfeffer, K., Müller, M., & Decker, T. (2003) · Immunity · doi:10.1016/s1074-7613(03)00322-4 · Cited by 284 · see citing works

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kubota, N., Kaneko, K., Kobayashi, M., Iwane, A., Sasako, T., Okazaki, Y., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.010 · Cited by 277 · see citing works

The Jak/STAT pathway is involved in synaptic plasticity

Nicolas, C. S., Peineau, S., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, V. J., Hildebrandt, L., Seaton, G., Choi, S.-L., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.024 · Cited by 246 · see citing works

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Zhou, H., Bai, L., Xu, R., Zhao, Y., Chen, J., McEachern, D., Chinnaswamy, K., Wen, B., Dai, L., Kumar, P., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01530 · Cited by 233 · see citing works

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

Platanitis, E., Demiroz, D., Schneller, A., Fischer, K., Capelle, C., Hartl, M., Gossenreiter, T., Müller, M., Novatchkova, M., & Decker, T. (2019) · Nature Communications · doi:10.1038/s41467-019-10970-y · Cited by 233 · see citing works

The c‐myc Promoter: Still MysterY and Challenge

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Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki

Sebe-Pedros, A., de Mendoza, A., Lang, B. F., Degnan, B. M., & Ruiz-Trillo, I. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq309 · Cited by 195 · see citing works

STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation

Pedroza, M., Le, T. T., Lewis, K., Karmouty‐Quintana, H., To, S., George, A. T., Blackburn, M. R., Tweardy, D. J., & Agarwal, S. K. (2016) · The FASEB Journal · doi:10.1096/fj.15-273953 · Cited by 193 · see citing works

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair

Fu, S., Li, Z., Xiao, L., Hu, W., Zhang, L., Xie, B., Zhou, Q., He, J., Qiu, Y., Wen, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.002 · Cited by 169 · see citing works

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

Schuringa, J. J., Chung, K. Y., Morrone, G., & Moore, M. A. S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041024 · Cited by 140 · see citing works

Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU. 1 complex

Kanno, Y., Levi, B.-Z., Tamura, T., & Ozato, K. (2005) · Journal of Interferon &amp; Cytokine Research · doi:10.1089/jir.2005.25.770 · Cited by 128 · see citing works

STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF

Pechkovsky, D. V., Prêle, C. M., Wong, J., Hogaboam, C. M., McAnulty, R. J., Laurent, G. J., Zhang, S. S.-M., Selman, M., Mutsaers, S. E., & Knight, D. A. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.12.022 · Cited by 127 · see citing works

Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy

Amaral, M. E. C., Cunha, D. A., Anhê, G. F., Ueno, M., Carneiro, E. M., Velloso, L. A., Bordin, S., & Boschero, A. C. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05547 · Cited by 110 · see citing works

Hybrid optimization method with general switching strategy for parameter estimation.

Balsa-Canto, E., Peifer, M., Banga, J. R., Timmer, J., & Fleck, C. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-26 · Cited by 105 · see citing works

Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring

Schlessinger, J., & Lemmon, M. A. (2006) · Cell · doi:10.1016/j.cell.2006.09.013 · Cited by 98 · see citing works

Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation

Singh, S. P., Gundavarapu, S., Peña-Philippides, J. C., Rir-sima-ah, J., Mishra, N. C., Wilder, J. A., Langley, R. J., Smith, K. R., & Sopori, M. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101567 · Cited by 93 · see citing works

Characterization of the Nuclear Factor-κB Responsiveness of the Human dio2 Gene

Zeöld, A., Doleschall, M., Haffner, M. C., Capelo, L. P., Menyhért, J., Liposits, Z., da Silva, W. S., Bianco, A. C., Kacskovics, I., Fekete, C., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1608 · Cited by 72 · see citing works

Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension

Johnson, A. W., Kinzenbaw, D. A., Modrick, M. L., & Faraci, F. M. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00299 · Cited by 63 · see citing works

Molecular pathogenesis of acute promyelocytic leukaemia and APL variants

Sirulnik, A., Melnick, A., Zelent, A., & Licht, J. D. (2003) · Best Practice &amp; Research Clinical Haematology · doi:10.1016/s1521-6926(03)00062-8 · Cited by 54 · see citing works

Iron regulates T-lymphocyte sensitivity to the IFN-γ/STAT1 signaling pathway in vitro and in vivo

Regis, G., Bosticardo, M., Conti, L., De Angelis, S., Boselli, D., Tomaino, B., Bernabei, P., Giovarelli, M., & Novelli, F. (2005) · Blood · doi:10.1182/blood-2004-07-2686 · Cited by 50 · see citing works

IL-6, but not IFN-γ, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing

Regis, G., Icardi, L., Conti, L., Chiarle, R., Piva, R., Giovarelli, M., Poli, V, & Novelli, F. (2009) · Leukemia · doi:10.1038/leu.2009.139 · Cited by 47 · see citing works

IFNγR2 trafficking tunes IFNγ–STAT1 signaling in T lymphocytes

Regis, G., Conti, L., Boselli, D., & Novelli, F. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.12.002 · Cited by 48 · see citing works

Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3

Martincuks, A., Andryka, K., Küster, A., Schmitz-Van de Leur, H., Komorowski, M., & Müller-Newen, G. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.01.006 · Cited by 45 · see citing works

Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway.

Zhang, H.-Y., Jin, X.-B., & Lue, T. F. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.162 · Cited by 39 · see citing works

Signalling Pathways Activated by All- <i>trans</i> -Retinoic Acid in Acute Promyelocytic Leukemia Cells

Kambhampati, S., Verma, A., Li, Y., Parmar, S., Sassano, A., & Platanias, L. (2004) · Leukemia &amp; Lymphoma · doi:10.1080/10428190410001722053 · Cited by 29 · see citing works

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses

Kroczynska, B., Rafidi, R. L., Majchrzak-Kita, B., Kosciuczuk, E. M., Blyth, G. T., Jemielity, J., Warminska, Z., Saleiro, D., Mehrotra, S., Arslan, A. D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.664995 · Cited by 29 · see citing works

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

Martinez-Fabregas, J., Wang, L., Pohler, E., Cozzani, A., Kazemian, M., Mitra, S., & Moraga, I. (2020) · doi:10.1101/2020.03.19.998351 · Cited by 2 · see citing works