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MCM Proteins in DNA Replication
Abstract
▪ Abstract The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best known among them are a family of six structurally related proteins, MCM2–7, which are evolutionally conserved in all eukaryotes. The MCM2–7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. New evidence suggests that the MCM2–7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2–7 proteins and other components of the prereplication complex by cell cycle–dependent protein kinases results in initiation of DNA synthesis once every cell cycle.
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Cited by
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Initiating DNA synthesis: from recruiting to activating the MCM complex
Lei, M., & Tye, B. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1447 · Cited by 365
Self-citationMeier, F., Geyer, P. E., Virreira Winter, S., Cox, J., & Mann, M. (2018) · Nature Methods · doi:10.1038/s41592-018-0003-5 · Cited by 348
Fischer, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf590 · Cited by 294
Scholes, D. T., Banerjee, M., Bowen, B., & Curcio, M. J. (2001) · Genetics · doi:10.1093/genetics/159.4.1449 · Cited by 235
Metadata
- Authors
- Tye, B. K.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1999-06
- Volume
- 68
- Issue
- 1
- Pages
- 649-686
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2168215139
- Cited by
- 664
- References
- 0
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
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