Multiple Regulators of Ty1 Transposition in Saccharomyces cerevisiae Have Conserved Roles in Genome Maintenance

Scholes, Derek T; Banerjee, Mukti; Bowen, Brian; Curcio, M Joan

doi:10.1093/genetics/159.4.1449

Cited by 235Chromosomal and Genetic VariationsFungal and yeast genetics researchDNA Repair Mechanisms

Multiple Regulators of Ty1 Transposition in Saccharomyces cerevisiae Have Conserved Roles in Genome Maintenance

Scholes, Derek T, Banerjee, Mukti, Bowen, Brian, Curcio, M Joan·2001·Genetics

DOI 10.1093/genetics/159.4.1449

Open this paper in CoChat — free account

Abstract

Most Ty1 retrotransposons in the genome of Saccharomyces cerevisiae are transpositionally competent but rarely transpose. We screened yeast mutagenized by insertion of the mTn3-lacZ/LEU2 transposon for mutations that result in elevated Ty1 cDNA-mediated mobility, which occurs by cDNA integration or recombination. Here, we describe the characterization of mTn3 insertions in 21 RTT (regulation of Ty1 transposition) genes that result in 5- to 111-fold increases in Ty1 mobility. These 21 RTT genes are EST2, RRM3, NUT2, RAD57, RRD2, RAD50, SGS1, TEL1, SAE2, MED1, MRE11, SCH9, KAP122, and 8 previously uncharacterized genes. Disruption of RTT genes did not significantly increase Ty1 RNA levels but did enhance Ty1 cDNA levels, suggesting that most RTT gene products act at a step after mRNA accumulation but before cDNA integration. The rtt mutations had widely varying effects on integration of Ty1 at preferred target sites. Mutations in RTT101 and NUT2 dramatically stimulated Ty1 integration upstream of tRNA genes. In contrast, a mutation in RRM3 increased Ty1 mobility >100-fold without increasing integration upstream of tRNA genes. The regulation of Ty1 transposition by components of fundamental pathways required for genome maintenance suggests that Ty1 and yeast have coevolved to link transpositional dormancy to the integrity of the genome.

Integrity signals

Registry

Crossref · 10.1093/genetics/159.4.1449

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An increase in mRNA levels of 'Transposition' genes such as retrotransposons is probably linked to the effect of Rtt106 as a Regulator of Ty1 Transposition (RTT).
“An increase in mRNA levels of ‘Transposition’ genes such as retrotransposons (Fig. 3b) is probably linked to the effect of Rtt106 as a Regulator of Ty1 Transposition (RTT)43, the phenotype for which Rtt106 was originally identified.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [43]

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,685 · see citing works
Methods in Yeast Genetics
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911 · see citing works
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953 · see citing works
Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E. M., Li, J., Hieter, P., & Boeke, J. D. (1998) · Yeast · doi:10.1002/(sici)1097-0061(19980130)14:2 · Cited by 3,411 · see citing works
The Significance of Responses of the Genome to Challenge
McClintock, B. (1984) · Science · doi:10.1126/science.15739260 · Cited by 2,638 · see citing works
Functional Discovery via a Compendium of Expression Profiles
Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534 · see citing works
The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450 · see citing works
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
Kim, Y.-J., Björklund, S., Li, Y., Sayre, M. H., & Kornberg, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90221-6 · Cited by 1,080 · see citing works
A mutant with a defect in telomere elongation leads to senescence in yeast
Lundblad, V., & Szostak, J. W. (1989) · Cell · doi:10.1016/0092-8674(89)90132-3 · Cited by 909 · see citing works
A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains
Alani, E., Cao, L., & Kleckner, N. E. (1987) · Genetics · doi:10.1534/genetics.112.541.test · Cited by 878 · see citing works
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works
Ty elements transpose through an RNA intermediate
Boeke, J. D., Garfinkel, D. J., Styles, C. A., & Fink, G. R. (1985) · Cell · doi:10.1016/0092-8674(85)90197-7 · Cited by 822 · see citing works
A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.1.9034168 · Cited by 746 · see citing works
TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase
Singer, M. S., & Gottschling, D. E. (1994) · Science · doi:10.1126/science.7545955 · Cited by 736 · see citing works
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L. B., & Rothstein, R. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8391 · Cited by 677 · see citing works
MCM Proteins in DNA Replication
Tye, B. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.649 · Cited by 666 · see citing works
Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.
Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540 · see citing works
Transposable Elements and Genome Organization: A Comprehensive Survey of Retrotransposons Revealed by the Complete Saccharomyces cerevisiae Genome SequencePreprint
Kim, J. M., Vanguri, S., Boeke, J. D., Gabriel, A., & Voytas, D. F. (1998) · Genome Research · doi:10.1101/gr.8.5.464 · Cited by 534 · see citing works
A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
Marcand, S., Gilson, E., & Shore, D. (1997) · Science · doi:10.1126/science.275.5302.986 · Cited by 524 · see citing works
Senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
Lendvay, T. S., Morris, D. K., Sah, J., Balasubramanian, B., & Lundblad, V. (1996) · Genetics · doi:10.1093/genetics/144.4.1399 · Cited by 505 · see citing works
The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor
Huang, M., Zhou, Z., & Elledge, S. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81601-3 · Cited by 499 · see citing works
Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.Preprint
Burns, N. A., Grimwade, B. G., Ross‐Macdonald, P., Choi, E. Y., Finberg, K. E., Roeder, G. S., & Snyder, M. P. (1994) · Genes & Development · doi:10.1101/gad.8.9.1087 · Cited by 490 · see citing works
ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity
Ohta, T., Michel, J. J. C., Schottelius, A. J. G., & Xiong, Y. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80482-7 · Cited by 461 · see citing works
Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae
Teng, S., & Zakian, V. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8083 · Cited by 457 · see citing works
A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains
Alani, E. A., Cao, L., & Kleckner, N. E. (1987) · Genetics · doi:10.1093/genetics/116.4.541 · Cited by 417 · see citing works
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Preprint
Wotton, D., & Shore, D. (1997) · Genes & Development · doi:10.1101/gad.11.6.748 · Cited by 412 · see citing works
The Many Interfaces of Mre11
Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81626-8 · Cited by 407 · see citing works
Proliferating bipotential glial progenitor cells in adult rat optic nerve
ffrench‐Constant, C., & RAFF, M. C. (1986) · Nature · doi:10.1038/319499a0 · Cited by 385 · see citing works
A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex
Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384 · see citing works
SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae
Watt, P. M., Hickson, I. D., Borts, R. H., & Louis, E. J. (1996) · Genetics · doi:10.1093/genetics/144.3.935 · Cited by 380 · see citing works
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
Greenwell, P. W., Kronmal, S., Porter, S. E., Gassenhuber, J., Obermaier, B., & Petes, T. D. (1995) · Cell · doi:10.1016/0092-8674(95)90479-4 · Cited by 379 · see citing works
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1
Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90480-8 · Cited by 370 · see citing works
The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.Preprint
Myers, L., Gustafsson, C., Bushnell, D., Lui, M., Erdjument-Bromage, H., Tempst, P., & Kornberg, R. (1998) · Genes & Development · doi:10.1101/gad.12.1.45 · Cited by 329 · see citing works
Nuclear pore complexes in the organization of silent telomeric chromatin
Galy, V., Olivo‐Marín, J., Scherthan, H., et al. (2000) · Nature · doi:10.1038/47528 · Cited by 318 · see citing works
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.Preprint
Elledge, S. J., & Davis, R. W. (1990) · Genes & Development · doi:10.1101/gad.4.5.740 · Cited by 311 · see citing works
CIp10, an efficient and convenient integrating vector for Candida albicans
Murad, A. M. A., Lee, P. R., Broadbent, I. D., Barelle, C. J., & Brown, A. J. P. (2000) · Yeast · doi:10.1002/1097-0061(20000315)16:4 · Cited by 303 · see citing works
The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA
Ivessa, A., Zhou, J., & Zakian, V. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80683-2 · Cited by 274 · see citing works
Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting
Smith, V., Chou, K. N., Lashkari, D. A., Botstein, D., & Brown, P. O. (1996) · Science · doi:10.1126/science.274.5295.2069 · Cited by 266 · see citing works
Single-step selection for Ty1 element retrotransposition.
Curcio, M. J., & Garfinkel, D. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.936 · Cited by 263 · see citing works
Self-citation
Proteins Connecting the Nuclear Pore Complex with the Nuclear Interior
Strambio‐De‐Castillia, C., Blobel, G., & Rout, M. P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.5.839 · Cited by 231 · see citing works
Integration of the yeast retrotransposon Ty1 is targeted to regions upstream of genes transcribed by RNA polymerase III.Preprint
Devine, S. E., & Boeke, J. D. (1996) · Genes & Development · doi:10.1101/gad.10.5.620 · Cited by 228 · see citing works
Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences
Ji, H. P., Moore, D., Blomberg, M. A., Braiterman, L. T., Voytas, D. F., Natsoulis, G., & Boeke, J. D. (1993) · Cell · doi:10.1016/0092-8674(93)90278-x · Cited by 218 · see citing works
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.Preprint
Toda, T., Cameron, S., Sass, P. M., & Wigler, M. H. (1988) · Genes & Development · doi:10.1101/gad.2.5.517 · Cited by 197 · see citing works
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.
Goyer, C., Altmann, M., Lee, H. S., Blanc, A., Deshmukh, M., Woolford, J. L., Trachsel, H., & Sonenberg, N. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4860 · Cited by 183 · see citing works
The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast
Ritchie, K. B., & Petes, T. D. (2000) · Genetics · doi:10.1093/genetics/155.1.475 · Cited by 173 · see citing works
Fidelity of Mitotic Double-Strand-Break Repair in Saccharomyces cerevisiae: A Role for SAE2/COM1
Rattray, A. J., McGill, C. B., Shafer, B. K., & Strathern, J. N. (2001) · Genetics · doi:10.1093/genetics/158.1.109 · Cited by 138 · see citing works
DNA damage activates transcription and transposition of yeast Ty retrotransposons
Bradshaw, V. A., & McEntee, K. (1989) · Molecular and General Genetics MGG · doi:10.1007/bf00332411 · Cited by 127 · see citing works
A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.
Kawakami, K., Pande, S., Faiola, B., Moore, D., Boeke, J. D., Farabaugh, P. J., Strathern, J. N., Nakamura, Y., & Garfinkel, D. J. (1993) · Genetics · doi:10.1093/genetics/135.2.309 · Cited by 126 · see citing works
[22] Propagation and expression of cloned genes in yeast: 2-μm circle-based vectors
Rose, A. B., & Broach, J. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)85024-i · Cited by 113 · see citing works
TEC1, a Gene Involved in the Activation of Ty1 and Ty1-Mediated Gene Expression in Saccharomyces cerevisiae: Cloning and Molecular Analysis
Laloux, I., Dubois, E. L., Dewerchin, M. A., & Jacobs, E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3541 · Cited by 112 · see citing works
HSP78 encodes a yeast mitochondrial heat shock protein in the Clp family of ATP-dependent proteases.
Leonhardt, S. A., Fearson, K., Danese, P. N., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6304 · Cited by 110 · see citing works
Fitness effects of Ty transposition in Saccharomyces cerevisiae.
Wilke, C. M., & Adams, J. (1992) · Genetics · doi:10.1093/genetics/131.1.31 · Cited by 106 · see citing works
Hsp78, a Clp homologue within mitochondria, can substitute for chaperone functions of mt‐hsp70.
Schmitt, M., Neupert, W., & Langer, T. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07349.x · Cited by 105 · see citing works
Saccharomyces cerevisiae SPT3 gene is required for transposition and transpositional recombination of chromosomal Ty elements.
Boeke, J. D., Styles, C. A., & Fink, G. R. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3575 · Cited by 98 · see citing works
Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly.
Wang, Y. X., Zhao, H. F., Harding, T. M., et al. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1375 · Cited by 90 · see citing works
Ty RNA levels determine the spectrum of retrotransposition events that activate gene expression in Saccharomyces cerevisiae
Curcio, M. J., Hedge, A.-M., Boeke, J. D., et al. (1990) · Molecular and General Genetics MGG · doi:10.1007/bf00260484 · Cited by 90 · see citing works
Self-citation
Activation of the Kss1 Invasive-Filamentous Growth Pathway Induces Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae
Morillon, A., Springer, M., & Lesage, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5766-5776.2000 · Cited by 84 · see citing works
Induction of yeast Ty element transcription by ultraviolet light
Rolfe, M., Spanos, A., & Banks, G. R. (1986) · Nature · doi:10.1038/319339a0 · Cited by 81 · see citing works
Ty1 and Ty5 ofSaccharomyces cerevisiae
Voytas, D. F., & Boeke, J. D. (2007) · Wiley eBooks · doi:10.1128/9781555817954.ch26 · Cited by 79 · see citing works
RAMPAGE: Promoter Activity Profiling by Paired-End Sequencing of 5′-Complete cDNAs
Batut, P. J., & Gingeras, T. (2013) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb25b11s104 · Cited by 79 · see citing works
Posttranslational Control of Ty1 Retrotransposition Occurs at the Level of Protein Processing
Curcio, M. J., & Garfinkel, D. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2813 · Cited by 71 · see citing works
Self-citation
Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.
Picologlou, S., Brown, N., & Liebman, S. W. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.3.1017 · Cited by 69 · see citing works
Involvement of DNA End-Binding Protein Ku in Ty Element Retrotransposition
Downs, J. A., & Jackson, S. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6260 · Cited by 69 · see citing works
Evidence for the Role of Recombination in the Regulatory Evolution of Saccharomyces cerevisiae Ty Elements
Jordan, I. K., & McDonald, J. F. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006358 · Cited by 69 · see citing works
Localization of sequences required in cis for yeast Ty1 element transposition near the long terminal repeats: analysis of mini-Ty1 elements.
Xu, H., & Boeke, J. D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2695 · Cited by 68 · see citing works
Posttranslational Inhibition of Ty1 Retrotransposition by Nucleotide Excision Repair/Transcription Factor TFIIH Subunits Ssl2p and Rad3p
Lee, B.-S., Lichtenstein, C. P., Faiola, B., et al. (1998) · Genetics · doi:10.1093/genetics/148.4.1743 · Cited by 67 · see citing works
Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae
Rempoła, B., Kaniak, A., Migdalski, A., Rytka, J., Słonimski, P. P., & di Rago, J. (2000) · Molecular and General Genetics MGG · doi:10.1007/pl00008651 · Cited by 62 · see citing works
Heterogeneous functional Ty1 elements are abundant in the Saccharomyces cerevisiae genome.
Curcio, M. J., & Garfinkel, D. J. (1994) · Genetics · doi:10.1093/genetics/136.4.1245 · Cited by 62 · see citing works
Self-citation
Yeast Ty1 Retrotransposition Is Stimulated by a Synergistic Interaction between Mutations in Chromatin Assembly Factor I and Histone Regulatory Proteins
Qian, Z., Huang, H., Hong, J. Y., Burck, C., Johnston, S. D., Berman, J. G., Carol, A. M., & Liebman, S. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4783 · Cited by 58 · see citing works
Posttranslational Regulation of Ty1 Retrotransposition by Mitogen-Activated Protein Kinase Fus3
Conte, D., Barber, E., Banerjee, M., Garfinkel, D. J., & Curcio, M. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2502 · Cited by 56 · see citing works
Self-citation
Identification of New Mediator Subunits in the RNA Polymerase II Holoenzyme from Saccharomyces cerevisiae
Gustafsson, C. M., Myers, L. C., Béve, J., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30851 · Cited by 55 · see citing works
The Karyopherin Kap122p/Pdr6p Imports Both Subunits of the Transcription Factor Iia into the Nucleus
Titov, A. A., & Blobel, G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.235 · Cited by 54 · see citing works
The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression.
Balčiūnas, D., Galman, C., Ronne, H., & Björklund, S. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.2.376 · Cited by 54 · see citing works
Nuclear Proteins Nut1p and Nut2p Cooperate To Negatively Regulate a Swi4p-DependentlacZReporter Gene inSaccharomyces cerevisiae
Tabtiang, R. K., & Herskowitz, I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4707 · Cited by 52 · see citing works
A ubiquitin-conjugating enzyme, RAD6, affects the distribution of Ty1 retrotransposon integration positions.
Liebman, S. W., & Newnam, G. P. (1993) · Genetics · doi:10.1093/genetics/133.3.499 · Cited by 48 · see citing works
The Sgs1 Helicase of Saccharomyces cerevisiae Inhibits Retrotransposition of Ty1 Multimeric Arrays
Bryk, M., Banerjee, M., Conte, D., & Curcio, M. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5374-5388.2001 · Cited by 47 · see citing works
Self-citation
Activation of Ty transposition by mutagens
Staleva, L., & Venkov, P. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00165-2 · Cited by 46 · see citing works
Nucleotide Excision Repair/TFIIH Helicases Rad3 and Ssl2 Inhibit Short-Sequence Recombination and Ty1 Retrotransposition by Similar Mechanisms
Lee, B.-S., Bi, L., Garfinkel, D. J., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2436-2445.2000 · Cited by 46 · see citing works
The Saccharomyces cerevisiae DNA Recombination and Repair Functions of the RAD52 Epistasis Group Inhibit Ty1 Transposition
Rattray, A. J., Shafer, B. K., & Garfinkel, D. J. (2000) · Genetics · doi:10.1093/genetics/154.2.543 · Cited by 43 · see citing works
Fus3 controls Ty1 transpositional dormancy through the invasive growth MAPK pathway
Conte, D., & Curcio, M. J. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01710.x · Cited by 40 · see citing works
Self-citation
Transpositional competence and transcription of endogenous Ty elements in Saccharomyces cerevisiae: implications for regulation of transposition.
Curcio, M. J., Sanders, N. J., & Garfinkel, D. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3571 · Cited by 37 · see citing works
Self-citation
Host Genes That Affect the Target-Site Distribution of the Yeast Retrotransposon Ty1
Huang, H., Hong, J. Y., Burck, C., et al. (1999) · Genetics · doi:10.1093/genetics/151.4.1393 · Cited by 22 · see citing works
Effect of irradiation and mutagenic chemicals on the generation of ADH2- and ADH4-constitutive mutants in yeast: the inducibility of Ty transposition by UV and ethyl methanesulfonate
Morawetz, C., & Hagen, U. (1990) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(90)90009-s · Cited by 20 · see citing works
XIV . Yeast sequencing reports. A 21·7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function
Jonniaux, J.-L., Coster, F., Purnelle, B., et al. (1994) · Yeast · doi:10.1002/yea.320101213 · Cited by 10 · see citing works
10 Transposon Tagging I: A Novel System for Monitoring Protein Production, Function and Localization
Ross‐Macdonald, P., Sheehan, A. E., Friddle, C. J., et al. (1998) · Methods in microbiology · doi:10.1016/s0580-9517(08)70331-3 · Cited by 7 · see citing works

Flagged first, then by citations

Sorted by citations

Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56
Driscoll, R., Hudson, A., & Jackson, S. P. (2007) · Science · doi:10.1126/science.1135862 · Cited by 439 · see citing works
Chromatin and Transcription in Yeast
Rando, O. J., & Winston, F. (2012) · Genetics · doi:10.1534/genetics.111.132266 · Cited by 269 · see citing works
Host factors exploited by retroviruses
Goff, S. P. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1541 · Cited by 247 · see citing works
Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing
Huang, S., Zhou, H., Katzmann, D., Hochstrasser, M., Atanasova, E., & Zhang, Z. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506176102 · Cited by 130 · see citing works
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast
Flott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P., & Rouse, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00135-07 · Cited by 107 · see citing works
A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon
Baller, J. A., Gao, J., Stamenova, R., Curcio, M. J., & Voytas, D. F. (2012) · Genome Research · doi:10.1101/gr.129585.111 · Cited by 61 · see citing works
Self-citation
SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes
Nikolov, V. N., Malavia, D., & Kubota, T. (2022) · Nature Communications · doi:10.1038/s41467-022-29591-z · Cited by 16 · see citing works

What do we still need to know about transposable element Ac?
Starlinger, P. (1993) · Gene · doi:10.1016/0378-1119(93)90073-c · Cited by 8 · see citing works
Transposable genetic elements inSpirulina and potential applications for genetic engineering
Kojima, H., Qin, S., Kumar, T. A., et al. (1998) · Chinese Journal of Oceanology and Limnology · doi:10.1007/bf02849077 · Cited by 4 · see citing works
Effects of deletions in transposon Tn7 on its frequency of transposition
SMITH, G. M., & Jones, P. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.3.962-964.1984 · Cited by 19 · see citing works
Current Advances in the Studies of Sleeping Beauty Transposition
Xin-fang, L. (2006) · Letters in Biotechnology
Genetic Organization of Tn5Preprint
Rothstein, S. J., Jorgensen, R. A., Yin, J., et al. (1981) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1981.045.01.018 · Cited by 65 · see citing works

Authors: Scholes, D. T., Banerjee, M., Bowen, B., & Curcio, M. J.
Affiliations: State University of New York (US)
Corresponding author: Curcio, M Joan
ORCID: Curcio, M Joan
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 2001-12-01
Volume: 159
Issue: 4
Pages: 1449-1465
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/159.4.1449
OpenAlex: W2101107183
Cited by: 235
References: 85
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 11
FWCI: 14.60
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM052072, GM-52072)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: Ty1 retrotransposon, transposition regulation, genome maintenance, RRM3, tRNA genes, Saccharomyces cerevisiae
MeSH terms: DNA Damage, Genes, Fungal, Models, Genetic, Mutation, Plasmids, RNA, Saccharomyces cerevisiae, Transcription, Genetic, Blotting, Northern, Mutagenesis, Telomere, Genome, DNA, Complementary, Retroelements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multiple Regulators of Ty1 Transposition in Saccharomyces cerevisiae Have Conserved Roles in Genome Maintenance

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks