The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Regulation of Chromosome Replication
Abstract
▪ Abstract The initiation of DNA replication in eukaryotic cells is tightly controlled to ensure that the genome is faithfully duplicated once each cell cycle. Genetic and biochemical studies in several model systems indicate that initiation is mediated by a common set of proteins, present in all eukaryotic species, and that the activities of these proteins are regulated during the cell cycle by specific protein kinases. Here we review the properties of the initiation proteins, their interactions with each other, and with origins of DNA replication. We also describe recent advances in understanding how the regulatory protein kinases control the progress of the initiation reaction. Finally, we describe the checkpoint mechanisms that function to preserve the integrity of the genome when the normal course of genome duplication is perturbed by factors that damage the DNA or inhibit DNA synthesis.
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Cited by
Genome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N., Kanin, E., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,766
Genome‐scale models of metabolism and gene expression extend and refine growth phenotype prediction
O'Brien, E. J., Lerman, J. A., Chang, R. L., Hyduke, D. R., & Palsson, B. Ø. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.52 · Cited by 471
S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function
Cliby, W. A., Lewis, K. A., Lilly, K. K., & Kaufmann, S. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106287200 · Cited by 205
Uranbileg, B., Yamamoto, H., Park, J.-H., Mohanty, A. R., Arakawa-Takeuchi, S., Jinno, S., & Okayama, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.318295 · Cited by 19
ATP-dependent activation of p21 WAF1/CIP1 -associated Cdk2 by Cdc6
Kan, Q., Jinno, S., Yamamoto, H., Kobayashi, K., & Okayama, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706392105 · Cited by 19
Metadata
- Authors
- Kelly, T. J., & Brown, G. W.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2000-06
- Volume
- 69
- Issue
- 1
- Pages
- 829-880
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2110902629
- Cited by
- 401
- References
- 15
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
