The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Genome-Wide Location and Function of DNA Binding Proteins
Abstract
Understanding how DNA binding proteins control global gene expression and chromosomal maintenance requires knowledge of the chromosomal locations at which these proteins function in vivo. We developed a microarray method that reveals the genome-wide location of DNA-bound proteins and used this method to monitor binding of gene-specific transcription activators in yeast. A combination of location and expression profiles was used to identify genes whose expression is directly controlled by Gal4 and Ste12 as cells respond to changes in carbon source and mating pheromone, respectively. The results identify pathways that are coordinately regulated by each of the two activators and reveal previously unknown functions for Gal4 and Ste12. Genome-wide location analysis will facilitate investigation of gene regulatory networks, gene function, and genome maintenance.
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Cites
Spellman, P. T., Sherlock, G., Zhang, M. Q., Iyer, V. R., Anders, K., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,722
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
Lee, T. I., & Young, R. A. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.77 · Cited by 860
Self-citationRoberts, C. J., Nelson, B., Marton, M. J., Stoughton, R., Meyer, M. R., Bennett, H. A., He, Y. D., Dai, H., Walker, W. L., Hughes, T. R., et al. (2000) · Science · doi:10.1126/science.287.5454.873 · Cited by 855
DNA recognition by GAL4: structure of a protein-DNA complex
Marmorstein, R., Carey, M., Ptashne, M., & Harrison, S. C. (1992) · Nature · doi:10.1038/356408a0 · Cited by 662
Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation
Orlando, V. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01535-2 · Cited by 506
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 401
Chang, F., & Herskowitz, I. (1990) · Cell · doi:10.1016/0092-8674(90)90503-7 · Cited by 394
INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
Dutta, A., & Bell, S. P. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.293 · Cited by 393
Self-citationTranscriptional regulation through Mediator-like coactivators in yeast and metazoan cells
Malik, S., & Roeder, R. G. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01596-6 · Cited by 370
Cited by
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
The Human Transcription Factors
Lambert, S. A., Jolma, A., Campitelli, L. F., Das, P. K., Yin, Y., Albu, M., Chen, X., Taipale, J., Hughes, T. R., & Weirauch, M. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.029 · Cited by 3,399
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
Self-citationNext-Generation DNA Sequencing Methods
Mardis, E. R. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164359 · Cited by 2,369
Metadata
- Authors
- Ren, B., Robert, F., Wyrick, J. J., Aparicio, O., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N., Kanin, E., Volkert, T. L., Wilson, C. J., Bell, S. P., & Young, R. A.
- Venue
- Science
- Published
- 2000-12-22
- Volume
- 290
- Issue
- 5500
- Pages
- 2306-2309
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4248318091
- Cited by
- 1,766
- References
- 20
- FWCI
- 23.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ren, B., Robert, F., Wyrick, J. J., Aparicio, O., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N., Kanin, E., Volkert, T. L., Wilson, C. J., Bell, S. P., & Young, R. A. (2000). Genome-Wide Location and Function of DNA Binding Proteins. Science. https://doi.org/10.1126/science.290.5500.2306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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