The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Dynamics of Chromosome Organization and Gene Regulation
Abstract
▪ Abstract With the sequence of the human genome now complete, studies must focus on how the genome is functionally organized within the confines of the cell nucleus and the dynamic interplay between the genome and its regulatory factors to effectively control gene expression and silencing. In this review I describe our current state of knowledge with regard to the organization of chromosomes within the nucleus and the positioning of active versus inactive genes. In addition, I discuss studies on the dynamics of chromosomes and specific genetic loci within living cells and its relationship to gene activity and the cell cycle. Furthermore, our current understanding of the distribution and dynamics of RNA polymerase II transcription factors is discussed in relation to chromosomal loci and other nuclear domains.
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Citations
Cites
The sequence of the human genome
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Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802
Kinetics of Core Histones in Living Human Cells
Kimura, H., & Cook, P. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1341 · Cited by 675
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Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones
Freeman, B. C., & Yamamoto, K. R. (2002) · Science · doi:10.1126/science.1073051 · Cited by 400
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Cited by
Interchromosomal associations between alternatively expressed loci
Spilianakis, C. G., Lalioti, M. D., Town, T., Lee, G. R., & Flavell, R. A. (2005) · Nature · doi:10.1038/nature03574 · Cited by 730
Chromosome territories – a functional nuclear landscape
Cremer, T., Cremer, M., Dietzel, S., Müller, S., Solovei, I., & Fakan, S. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.04.007 · Cited by 599
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope
Cabal, G. G., Genovesio, A., Rodriguez-Navarro, S., Zimmer, C., Gadal, O., Lesne, A., Buc, H., Feuerbach-Fournier, F., Olivo-Marin, J.-C., Hurt, E. C., et al. (2006) · Nature · doi:10.1038/nature04752 · Cited by 465
The new cytogenetics: blurring the boundaries with molecular biology
Speicher, M. R., & Carter, N. P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1692 · Cited by 458
The nuclear envelope and transcriptional control
Akhtar, A., & Gasser, S. M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2122 · Cited by 441
Metadata
- Authors
- Spector, D. L.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2003-06
- Volume
- 72
- Issue
- 1
- Pages
- 573-608
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2101814873
- Cited by
- 341
- References
- 10
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spector, D. L. (2003). The Dynamics of Chromosome Organization and Gene Regulation. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.72.121801.161724
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
