The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanism of Mo-Dependent Nitrogenase
Open accessAbstract
Nitrogen-fixing bacteria catalyze the reduction of dinitrogen (N 2) to two ammonia molecules (NH 3), the major contribution of fixed nitrogen to the biogeochemical nitrogen cycle. The most widely studied nitrogenase is the molybdenum (Mo)-dependent enzyme. The reduction of N 2 by this enzyme involves the transient interaction of two component proteins, designated the iron (Fe) protein and the MoFe protein, and minimally requires 16 magnesium ATP (MgATP), eight protons, and eight electrons. The current state of knowledge on how these proteins and small molecules together effect the reduction of N 2 to ammonia is reviewed. Included is a summary of the roles of the Fe protein and MgATP hydrolysis, information on the roles of the two metal clusters contained in the MoFe protein in catalysis, insights gained from recent success in trapping substrates and inhibitors at the active-site metal cluster FeMo cofactor, and finally, considerations of the mechanism of N 2 reduction catalyzed by nitrogenase.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure–function relationships of alternative nitrogenases
Eady, R. R. (1996) · Chemical Reviews · doi:10.1021/cr950057h · Cited by 877
Cited by
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO 2 Fixation
Appel, A. M., Bercaw, J. E., Bocarsly, A. B., Dobbek, H., DuBois, D. L., Dupuis, M., Ferry, J. G., Fujita, E., Hille, R., Kenis, P. J. A., et al. (2013) · Chemical Reviews · doi:10.1021/cr300463y · Cited by 2,193
Self-citationMechanism of Nitrogen Fixation by Nitrogenase: The Next Stage
Hoffman, B. M., Lukoyanov, D., Yang, Z.-Y., Dean, D. R., & Seefeldt, L. C. (2014) · Chemical Reviews · doi:10.1021/cr400641x · Cited by 1,766
Self-citationCatalysts for nitrogen reduction to ammonia
Foster, S. L., Bakovic, S. I. P., Duda, R. D., Maheshwari, S., Milton, R. D., Minteer, S. D., Janik, M. J., Renner, J. N., & Greenlee, L. F. (2018) · Nature Catalysis · doi:10.1038/s41929-018-0092-7 · Cited by 1,633
Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase
Spatzal, T., Perez, K. A., Einsle, O., Howard, J. B., & Rees, D. C. (2014) · Science · doi:10.1126/science.1256679 · Cited by 401
A review on biomass based hydrogen production technologies
Pal, D. B., Singh, A., & Bhatnagar, A. (2022) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2021.10.124 · Cited by 322
Metadata
- Authors
- Seefeldt, L. C., Hoffman, B. M., & Dean, D. R.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 701-722
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2104684144
- Cited by
- 682
- References
- 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanism of Mo-Dependent Nitrogenase. https://app.cochat.ai/papers/10.1146/annurev.biochem.78.070907.103812
- The paper
- Seefeldt, L. C., Hoffman, B. M., & Dean, D. R. (2009). Mechanism of Mo-Dependent Nitrogenase. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.78.070907.103812
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
