The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin
Abstract
Interaction of cells with the extracellular matrix is fundamental to a wide variety of biological processes, such as cell proliferation, cell migration, embryogenesis, and organization of cells into tissues, and defects in cell-matrix interactions are an important element in many diseases. Cell-matrix interactions are frequently mediated by the integrin family of cell adhesion molecules, transmembrane alphabeta-heterodimers that are typically linked to the actin cytoskeleton by one of a number of adaptor proteins including talin, alpha-actinin, filamin, tensin, integrin-linked kinase, melusin, and skelemin. The focus of this review is talin, which appears unique among these proteins in that it also induces a conformational change in integrins that is propagated across the membrane, and increases the affinity of the extracellular domain for ligand. Particular emphasis is given to recent progress on the structure of talin, its interaction with binding partners, and its mode of regulation.
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Cites
Rapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
Self-citationType Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W., & Anderson, R. A. (2002) · Nature · doi:10.1038/nature01082 · Cited by 443
Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Barsukov, I. L., Prescot, A., Bate, N., Patel, B., Floyd, D. N., Bhanji, N., Bagshaw, C. R., Letinic, K., Di Paolo, G., De Camilli, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303850200 · Cited by 95
Self-citation
Cited by
Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
McEver, R. P. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv154 · Cited by 575
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
Talin – the master of integrin adhesions
Klapholz, B., & Brown, N. H. (2017) · Journal of Cell Science · doi:10.1242/jcs.190991 · Cited by 309
Talin as a mechanosensitive signaling hub
Goult, B. T., Yan, J., & Schwartz, M. A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201808061 · Cited by 250
Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X., & Sheetz, M. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001223 · Cited by 215
Metadata
- Authors
- Critchley, D. R.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2009-06
- Volume
- 38
- Issue
- 1
- Pages
- 235-254
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2124903948
- Cited by
- 278
- References
- 4
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
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