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Protein Import into the Cell Nucleus
Abstract
It has been known for some time that the uptake of proteins by the nucleus is extremely selective (Gurdon 1970; Bonner 1975b) and that mature nuclear proteins are able to accumulate in the nucleus (Gurdon 1970; Bonner 1975b; De Robertis et al 1978; Dabauvalle & Franke 1982). Nuclear proteins must therefore contain within their final structure a signal that specifies selective accumulation in the nucleus (De Robertis et al 1978). The study of the mechanisms by which proteins are selectively accumu lated in the cell nucleus has lagged behind the study of other transport processes, such as those that direct proteins to the cell exterior or to cytoplasmic organelles. The late development of this field may be due to the widespread acceptance of a model for nuclear localization in which
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Cited by
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
Grilli, M., Chiu, J. J.-S., & Lenardo, M. J. (1993) · International Review of Cytology · doi:10.1016/s0074-7696(08)61873-2 · Cited by 936
Fakharzadeh, S. S., Trusko, S. P., & George, D. L. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07676.x · Cited by 704
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631
Garcia-Bustos, J., Heitman, J., & Hall, M. N. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(91)90013-m · Cited by 549
Metadata
- Authors
- Dingwall, C., & Laskey, R. A.
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1986-11
- Volume
- 2
- Issue
- 1
- Pages
- 367-390
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2173844423
- Cited by
- 525
- References
- 0
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dingwall, C., & Laskey, R. A. (1986). Protein Import into the Cell Nucleus. Annual Review of Cell Biology. https://doi.org/10.1146/annurev.cb.02.110186.002055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
