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Cited by 318

The DOI matches its Crossref record.

MITOTIC CHROMOSOME CONDENSATION

Koshland, Douglas, Strunnikov, Alexander·1996·Annual Review of Cell and Developmental Biology

Abstract

▪ Abstract In this chapter, we review the structure and composition of interphase and mitotic chromosomes. We discuss how these observations support the model that mitotic condensation is a deterministic process leading to the invariant folding of a given chromosome. The structural studies have also placed constraints on the mechanism of condensation and defined several activities needed to mediate condensation. In the context of these activities and structural information, we present our current understanding of the role of cis sites, histones, topoisomerase II, and SMC proteins in condensation. We conclude by using our current knowledge of mitotic condensation to address the differences in chromosome condensation observed from bacteria to humans and to explore the relevance of this process to other processes such as gene expression.

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Metadata

Authors
Koshland, D., & Strunnikov, A.
Venue
Annual Review of Cell and Developmental Biology
Published
1996-11
Volume
12
Issue
1
Pages
305-333
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W2167801066
Cited by
318
References
0
FWCI
2.23
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: MITOTIC CHROMOSOME CONDENSATION. https://app.cochat.ai/papers/10.1146/annurev.cellbio.12.1.305
The paper
Koshland, D., & Strunnikov, A. (1996). MITOTIC CHROMOSOME CONDENSATION. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.12.1.305

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.